Max convinces Dr. Sharpe to take a risk on his course of treatment and Bloom grapples with a difficult conversation. Meanwhile, Dr. Kapoor considers helping his son in a big way after some advice from a friend.

As Max fights for his life, New Amsterdam is in full swing with a pertinent heart surgery that is not covered by insurance and a potential nurses walk out. As the team feels Max's absence and the doctors find out that they may have to treat one of their own, Sharpe must finally come clean about Max's condition.

Max continues to work to solve underlying problems within the hospital despite his continuing struggles with treatment. Meanwhile, Reynolds makes the choice to do a costly surgery to determine an elusive diagnosis and Bloom must face her personal demons head-on.

Sharpe struggles when a case hits too close to home. Frome uncovers a patient's surprising past. Reynolds makes progress in his personal life after some difficult news.

When a history-making blizzard hits New York, Max and his staff must work together to keep the patients safe with few resources, even if it means taking to the streets of the city and braving the storm.

Reynolds struggles to help a young cystic fibrosis patient with curious symptoms. Kapoor finally comes face-to-face with Ella after their awkward encounter. Sharpe takes a major step in her personal life.

Max goes head-to-head with hospital administration when he comes up with a new plan for patients without insurance. Iggy struggles with an accusation brought against him. Sharpe navigates her role as deputy medical director.