After a bomb explosion devastates a residential apartment building, special agents Maggie Bell and Omar Adom “OA” Zidan of the New York office of the Federal Bureau of Investigation investigate a possible war between rival gangs – that is, until their prime suspects are discovered brutally murdered.

After a senator’s daughter is kidnapped and held for ransom, the FBI is called in to assist with finding the child before their time limit expires. However, in order to do so, they must dig into the senator’s past for clues to who did this to his family.

Maggie and OA are on a mission to find a couple who are behind a spree of violent armed robberies that resulted in the death of an off-duty police officer.

When the daughter of a wealthy family is kidnapped in an attempt to gain notorious internet fame, Maggie and OA discover the kidnapper’s plans go far beyond abduction in order to never be forgotten.

Maggie and Dana struggle to find justice for victims murdered by a serial killer who left a ghoulish mark on all of his victims, while the mayor limits the investigation in order to prevent economical loss.

An American diplomat is killed while being used as a pawn in a dangerous drug ring, and the team must work together to bring them down. Also, Jubal and OA try to help friends from their past fight off their inner demons.

After a decorated FBI agent is murdered, the team investigates and uncovers the man led a double life. Also, Maggie struggles with what information she should reveal to the agent’s widow, who is also her personal friend.

A woman with information about the death of Maggie’s husband is abducted, leading OA and the team to uncover a criminal operation larger than anyone imagined. Also, Dana puts her career in jeopardy when she stands by and allows Maggie to work on this case that has such a personal connection to her.

After a bomb detonates at a restaurant in Queens, the case becomes personal for OA, who grew up eating there. But what initially seems like a terrorist attack reveals itself to be more complex, and OA goes undercover to prevent another incident.

After the son of a prominent Mommy blogger is kidnapped, the team must sweep through her two million followers to find the culprit. Kristen continues to adjust to life as a field agent with her new partner.

After a front-running female presidential candidate, Valerie Caldwell, is targeted with a car bomb, OA and Maggie must hurry to track down the bomber before they strike again. The case leads them to wonder whether this person is targeting Caldwell for her political aspirations or something else.

After a shooting at a nightclub, it appears that the FBI may have ignored previous threats from a local white supremacist group. Also, Kristen wrestles with her commitment to the Bureau and her responsibility to her community.

After a Wall Street investor is murdered, the team is led to an insider-trading ring that uses unconventional methods to gain information. OA struggles to maintain confidence in his budding relationship with Mona.

A car crash results in the death of a photographer; Maggie sympathizes with his widow when she notices similarities with her own husband's death.

After a businessman with a history of harassment claims against him is killed, the team suspects the killer may be one of his many accusers.

When a U.S. attorney is found dead steps away from the body of a private escort, the team must piece together what connected the two seemingly random victims. Also, Jubal’s connection with one of the victims makes finding the killer much more personal.

After a truck filled with armour-piercing rifles is hijacked, the team works to discover who stole it, and what they have planned for the stolen weapons. A friend from OA's past returns to help with the case, but OA isn't sure he can trust him.

After the police ignore a desperate father's plea for help, he abducts a billionaire's daughter and holds her hostage in a near-impenetrable safe room until his own missing child is returned to him. Also, Jubal puts his hostage negotiation skills to the test.

The team races to stop an active serial killer after three women are found weighted down at the bottom of a lake, and Jubal looks into an old closed case after there are multiple similarities to the recent victims.

When the leader of a drug cartel and one of the world's most wanted men, Antonio Vargas, is apprehended by the team, the entire FBI headquarters is put at risk when his henchmen unveil a terroristic threat to free him. During the turmoil, Isobel must make the difficult decision whether to sacrifice her conscience or her career.

A shooting at a quinceañera leaves two dead, but the team believes they may not have been the intended targets. Also, Maggie is trapped between a rock and a hard place as the team decides the best plan of action for using a witness to take down the suspect.

As the team searches for a young girl who was kidnapped from a cabin during a family vacation, they discover that the abduction may be tied to a skeleton in her family's closet. Also, Maggie questions her relationship with Nestor when she learns he hasn't been completely honest with her.

The team must infiltrate a drug trafficking gang after the robbery of a chemical plant leaves two customs agents dead. Also, Nestor offers his help on the case, giving Maggie new insight into his character.

As the team hunts a killer who is fatally shooting seemingly unrelated targets, an experience on the job has new agent Tiffany Wallace examining the tension between her career as an FBI special agent and the responsibility she feels to her community as a Black woman.

After a bomb leaves three people dead, the team presses a reluctant informant to gather information from his close friends who are under suspicion. Also, OA finds tension in his relationship with his girlfriend, Mona, when they clash on where the informant’s rights lie.

When a political reporter is kidnapped and held without a ransom demand, the team must dig into her past relationships in order to pin down her assailant’s motive. Also, Isobel’s relationship comes under fire when the case makes a connection to her boyfriend, Ethan.

The team rushes to track down two doctors abducted by a desperate father willing to do anything to save his son. Also, Jubal's uncertainty in his family life affects his judgement during the hostage situation.

When the CEO of a major brokerage firm is shot and killed while surrounded by protesters, the team looks into who had the most to lose from his company's perceived manipulations. Also, Scola's previous Wall Street career and the reasons he left come to light as the financial details of the case begin to unfold.

When five prominent men are killed at a trendy New York City restaurant, the team’s investigation brings them into contact with a lieutenant in Antonio Vargas’ cartel, triggering a long-awaited showdown between Isobel and Vargas.

Maggie, OA and the team must stop a hacker who is disabling life-saving equipment in several New York City hospitals. Jubal's son waits for important surgery at one of the impacted hospitals.

The team hunts for a serial killer who is targeting young, homeless men. Also, Tiffany and Scola don’t see eye to eye on how to handle the case or the difference between partners and co-workers.

The team must track down a shooter targeting detectives from the same precinct and unit, while facing mounting tension from the NYPD. Also, Tiffany finds that her NYPD roots may be influencing her view of the situation.

After Rina is critically wounded while heading to work with Jubal, the team makes the chilling discovery that a vengeful Vargas orchestrated the shooting from behind bars and continues to target the rest of their team and their loved ones.

As the team investigates a string of jewellery store robberies that culminate in a double murder, they uncover a connection to a 16-year-old boy trying to survive the foster care system. Tiffany becomes personally invested after learning about the boy's ill-fated upbringing.

The team searches for an abducted college coed; Jubal has a tense encounter with Rina's mother.

Maggie goes under cover working in a bar to investigate an anti-government group that regularly gathers there; a single father on the periphery of the group begins to fear he's in danger of becoming collateral damage.

The team investigates an extremist gun group after an anti-gun lobbyist building is bombed; SAC Bashar dangles a possible promotion for OA.

The team realizes they have a cross-country serial killer on their hands; the case has ties to Isobel's father, Robert, and his hotel, leading to revelations about their fractured relationship.

After an immigration agent is fatally shot at a hockey game, the team attempts to find the shooter, who they believe may also be targeting Congressman Curtis Grange, who was at the same game.

OA is forced to confront one of his biggest fears when the team discovers that deadly sarin gas may have been sold to terrorists.

The murder of a TSA agent leads the team to hunt down a killer who is using drug mules to exploit airport security checkpoints. Also, OA struggles to cope with the aftermath of the sarin gas exposure and the 10th anniversary of his army friend's death in Afghanistan.

When a retired DEA agent is shot outside a bakery, the team works to determine if the victim’s past cases or current bouncer job are connected to the murder. Also, Nina and Tiffany clash over the use of an informant while they are paired during the investigation.

The team pivots when their sting operation to secure a massive bomb from an illegal broker leads them to discover that the device is already in the wrong hands. Also, Jubal’s promise to be present at his son’s birthday party is put to the test as the case continues to heat up.

When an officer is shot dead at a pawn shop along with the store’s owner, the team tries to figure out why a young, recent Ivy League dropout is tied to the crime.

As the team investigates a deadly robbery that garnered a cache of automatic weapons for the killers, they discover one of the perps is a classmate of Jubal’s son, who is reluctant to cooperate with the case.

When a wealthy accountant is gunned down for secretly testifying against a notorious drug lord, the team’s investigation leads Tiffany to ask for help from a friend who was formerly with the NYPD and is related to the dangerous crime boss.

As the team works to rescue a 5-year-old kidnapping victim, Scola suspects the boy’s mother isn’t being forthcoming about why her son was targeted. Also, Nina struggles to open up to Scola about matters in their relationship.

When a deadly truck heist arms the killers with enough ammonium nitrate to construct a massive bomb, the team discovers a link to a terrorist group Maggie is working to infiltrate.

A teen shows up at FBI headquarters with a large bag of fentanyl, seeking the team's protection from the men who shot his father; Nina goes to Scola with a proposal he is hesitant to accept.

The team jumps into action when analyst Kelly Moran is taken hostage.

After a mysterious bioweapon leaves two MTA workers dead and one injured, the team rushes to determine who is behind the attack and the location of their next target; Jubal’s past demons begin to surface.

The team investigates the murder of a professional informant after he's found dead outside an abandoned factory in Red Hook. Also, Maggie reconnects with an old colleague and mentor.

After a string of armed robberies targets various businesses, the team investigates a suspect who leads them to something much bigger; OA worries about his future when his investments begin to go south.

When an off-duty diplomatic security agent is fatally shot in New York City trying to apprehend someone, the team investigates if there's a connection to his time working in Croatia.

When the deputy commander of an Air National Guard Base is kidnapped and forced to give over access codes, the team must work quickly to find the suspect along with stolen ammunition. Also, Scola questions his own safety in the aftermath of a recent traumatic experience.

When a trucker is gunned down after a routine trip from Canada, all signs point the team to a noted criminal on the FBI’s Most Wanted Terrorists list. Also, Jubal gets to work with an old friend and colleague, Detective Jack Lombardo.

A drug dealer is shot in a federal park and the team sets out to look for his killer; Maggie's sister returns to New York and complicates the case.

All eyes are on the team when they try to find out who kidnapped the only child of a prominent U.S senator. The abduction also uncovers a potential link to a similar case that was pushed to the side by local authorities.

After finding a group of teens dead from a drug overdose, the team races to find the dangerous dealer and his supplier. Meanwhile, OA questions where he stands in his faith.