Jukai is a doctor who travels the land fitting prosthetic arms and legs to those who have lost their limbs in war. One day, on the riverbank he finds a baby missing most of its body parts. He decides to raise the child, who he names “Hyakkimaru”. Jukai provides the child with prostheses, but the time comes when Hyakkimaru sets out on a journey to recover his own body parts.

After entering Lord Daigo's domain, Dororo and Hyakkimaru hear tales of Banmon, the huge wall that is the last remnant of a fort that once stood on the border. Hyakkimaru squares off against the fox demon that haunts the wall.

Dororo and Hyakkimaru come across an abandoned, burnt-out temple, where they meet a man named Sabame who rules the surrounding area. Sabame invites the two of them to his residence and tells them the story behind the burnt-out temple and the ghoul that haunts it. However, Dororo and Hyakkimaru suspect that he might not be telling the truth.

Sabame has been feeding people to the demons to protect the village over which he rules. As Hyakkimaru once again confronts the demon moths, Dororo gets trapped in a storehouse.

The shark demon lets out a roar and attacks Dororo, who is tied up and unable to move. Meanwhile, a troop of soldiers commanded by Tahomaru is also approaching the cape.

Inside Daigo's castle, Lady Nui appears before the cell in which Dororo has been imprisoned. Meanwhile, Hyakkimaru is also approaching the castle as he tries to take back both his body and Dororo. Behind Hyakkimaru stands Midoro, who has transformed into a ghoul.