Jukai is a doctor who travels the land fitting prosthetic arms and legs to those who have lost their limbs in war. One day, on the riverbank he finds a baby missing most of its body parts. He decides to raise the child, who he names “Hyakkimaru”. Jukai provides the child with prostheses, but the time comes when Hyakkimaru sets out on a journey to recover his own body parts.

Dororo Onikimaru confronts Tanosuke, a manly slaughter. The sword he wields was a cursed decoy where the devil lives. Although barely dismissing Tanosuke, the military sword has passed over to the hands of the hands and the horsemans are manipulated by the weapon.

Jukai is reunited with a bloodied Hyakkimaru at the site of a recent battle, and finds out the truth of how Hyakkimaru and the demons are connected. Hyakkimaru asks Jukai for a new prosthetic leg, but...