A generation-old rivalry is rekindled.

A meeting of the mafia heads of Purvanchal masquerading as a Holi party leads to a fracas' that threatens to transform all equations.

The Gorakhpur wedding massacre is a thing of the past for Akhandanand Tripathi. His focus is now on the present - the business and conquering larger territory to remain the King of Mirzapur. Everyone who survived that violent night has come out a different person. Despite horrific memories, they know that survival is their only option.

The Tripathis, still unaware that Guddu and Golu are alive, continue to form new alliances. Munna impresses Bauji and Akhandanand with the way he has handled a negotiation. Akhandanand helps the Chief Minister of Uttar Pradesh close the wedding massacre chapter. Guddu, Golu and Dimpy who are still in hiding, reunite with a loyal partner and set their sights on Mirzapur.

Akhandanand’s woes in the bedroom lead him to the doors of a sexologist. Beena continues to be gripped by the traumatic incident she endured but finds a compelling reason to survive. Guddu has to push himself to think beyond his physical strength while Golu has to learn the ropes of the trade. They make use of Dimpy’s past friendship and end up sending the Tripathis a strong message.

Akhandanand reprimands Munna and Sharad for their impulsive actions. Bablu’s diary becomes a key in learning secrets about the Tripathi family for Golu. In order to impress Akhandanand Tripathi, Sharad introduces him and Munna to one of Bihar’s most powerful business family, the Tyagis. A fortunate coincidence triggers an unexpected alliance between parties that have a common goal.

There has been a huge setback in the Tripathi family’s business, Akhandanand smells a rat but uses this set back to his advantage. Munna is coerced in to taking a big step in his life which makes the Tripathis’ political alliances stronger. Ramakant is surprised to find an unexpected ally. Golu makes a business proposition to Shatrughan, but it falls through. The elections come to an end.

Sharad Shukla and JP Yadav successfully manage to dent Akhandanand’s political aspirations. JP Yadav then calls for a debauche celebration with Zarina in private. After suffering a significant personal loss, Guddu takes upon an unexpected responsibility and Shabnam agrees to help. Golu doesn’t take this too well as she feels Shabnam will come in the way of their larger objective.

Beena gives birth to a boy and is worried about the safety of the child. Lala is unhappy with Guddu’s closeness to Shabnam. Golu herself is in immense pain, questions what she has become. Maurya is frustrated with constant setbacks and decides to meet with the IG. Munna takes matters in his own hands when Maqbool’s lies are resurfaced. Loyalties are at stake as a repercussion of Munna’s actions.

Beena confronts the horrors of her past, leaving the Tripathi household in chaos. Munna’s new found power through Madhuri leads him to make a drastic confrontation with Akhandanand. Dadda calls for a meeting with Mama, Shatrughan and Bharat. Ramakant is forced to confront his own beliefs. Guddu and Golu assure Beena of the promise they made. Sharad looks to bring his plan to a conclusion.

While Ramakant is tried for the murder of SSP Maurya, Guddu and Golu's claim to the throne is questioned because Kaleen Bhaiya's body is missing. Madhuri vows to fulfill her father's mission of a crime free state.

Guddu and Golu kickstart the business again, but are still looking for a supply of opium which would allow them to establish control over Purvanchal's underworld. In the hunt for the same control, Sharad tries to crack a deal with one of Guddu's old allies, while Madhuri tries to eliminate Guddu.

Guddu cements his power over Mirzapur while Sharad finally makes a very strong ally. Golu receives a threat from Bharat. Ramakant turns down Robin's offer and faces danger in prison. Meanwhile Madhuri strategises to bring Guddu down in other ways.

Ramakant's case is in danger with the appearance of a new witness. In an attempt to save her father's opium business from collapsing, Shabnam turns to Guddu for help. Meanwhile Golu gets some much awaited information about the still missing Kaleen Bhaiya.

Golu plans an attack outside Mirzapur without Guddu. Guddu returns from Nepal to find Golu missing. Sharad senses something is amiss in Siwan and decides to shift his most guarded secret to Jaunpur.

Purvanchal is set ablaze with a gang war between Sharad and Guddu. Madhuri makes strong decisions to break the police-gangster nexus, while a ghost from the past resurfaces. Ramakant finds a purpose in prison, which catches Lala's attention.

Purvanchal is thrown into turmoil following the shocking incident in the jail. Dadda confronts his son, while Sharad and Bharat have a fallout as well. A baithak is called to resolve the gang feud.

Guddu goes down a dark downward spiral as he loses people close to him. A new judge is assigned before Ramakant's final hearing. Meanwhile, Saloni discovers her husband's secrets. IG Dubey is reinstated and is tasked with one mission: Capturing Guddu Pandit.

Beena is compelled to find safety after the fall of Guddu. Madhuri urges Sharad to let go of the past for a better future. Will Shatrughan be able to convince Saloni to keep his secret? A broken Dimpy wants to take matters into her own hands.

Golu returns to Mirzapur only to discover the chaos that ensued in her absence. Madhuri inaugurates Aam Bagh despite the threat of JP Yadav looming large. As Dussehra closes in, there is only one question: Who will ascend the throne of Mirzapur?