FBI Agent Jennifer Sampson suffers a traumatic loss when her daughter is tragically caught in the crossfire of a hit intended for Sampson. When Agent Paige Van Doren fields the call about the shooting and brings in Agent Amiel MacArthur, an intense manhunt for the shooter kicks into gear. Sampson's daughter, in critical condition, needs surgery that could leave her brain-damaged, and Sampson and her husband, Carl, disagree on how to proceed. Meanwhile, crime boss Jonah Malloy, a vicious antagonist but dedicated family man, is in New York for a big mob consortium when he gets some harsh and unexpected news — his wife, Janet, has been raped.

Malloy's worst instincts are brought out when his right hand man, Donovan Stubbin, informs him that his wife's rapist — a thug named Larry — is the cousin of one of Malloy's own men, Leon. Malloy sends Stubbin after Larry, whose cousin, Leon, is now forced to choose between family by blood — and family by association. Meanwhile, the search for the shooter of Special Agent Sampson's daughter continues.