本季首播。星際艦隊必須要再次召集傳奇人物尚路克畢凱與他的前艦員—克里斯多堡里歐斯、九之七、拉菲耶拉穆希克與艾格妮絲朱拉蒂博士—一起探索對星系造成威脅的太空異象。

畢凱發現自己陷入一個平行時間軸來到2400年，而他的世仇Q在那裡一手策畫了一個終極「試煉」。畢凱開始尋找自己信任的船員，同時想找出是什麼原因造就了這個反烏托邦未來。

畢凱和他的船員回到2024年的洛杉磯尋找「看守者」。這個人能幫助他們找出到底是哪段時間線出了差錯。九之七、拉菲和里歐斯得在400年前又完全陌生的過去摸索。同時畢凱和朱拉蒂必須要跟意想不到又危險的盟友收集情報。

當拯救未來的機會逐漸消逝，畢凱親自出馬解決問題，並且去找老朋友幫忙。同時里歐斯跟警方發生衝突：朱拉蒂跟博格皇后達成協議。

畢凱發現在過去的一個重要人物很可能跟時間線出問題關係密切：Q繼續操控時間線，並且把注意力放在宋亞當博士身上：拉菲和九之七冒險劫車搶救里歐斯:：同時朱拉蒂和博格皇后達成一項交易，現在她得承擔後果。

有了塔倫的幫忙，畢凱和船員改變身分參加一場在聯合太空任務前夕舉辦的晚會，為了保護瑞內畢凱。他們深信這位太空人能夠修復時間線：柯芮發現自己父親到底在從事什麼樣的駭人研究。

塔林冒險進入畢凱的潛意識，幫助將他從昏迷中喚醒，並面對他最黑暗的秘密和最深的恐懼。九之七和拉菲去尋找他們害怕被裡面的怪物屈服的朱拉蒂。里歐斯努力向特蕾莎隱瞞他的真實身份。

當木衛二任務即將要出發，畢凱和吉蘭必須想辦法從聯邦調查局的手中逃出去：九之七和拉菲找到了朱拉蒂，並且發現她已經不再是以前的她。

畢凱和他的船員得為生存奮戰，因為他們的世仇化身為新敵人，並且想殲滅他們。為了要活下來，畢凱必須面對自己過去的鬼魂：九之七和拉菲和朱拉蒂要來一場終極之戰。

在第二季的最終集，就在木衛二任務即將出發的幾個小時前，畢凱和船員們發現自己必須和時間賽跑好拯救未來。

After receiving a cryptic, urgent distress call from Dr. Beverly Crusher, Admiral Jean-Luc Picard enlists help from generations old and new to embark on one final adventure: a daring mission that will change Starfleet, and his old crew forever.

Aided by Seven of Nine and the crew of the U.S.S. Titan, Picard makes a shocking discovery that will alter his life forever – and puts him on a collision course with the most cunning enemy he’s ever encountered. Meanwhile, Raffi races to track a catastrophic weapon – and collides with a familiar ally.

Picard grapples with an explosive, life-altering revelation, while the Titan and her crew try to outmaneuver a relentless Vadic in a lethal game of nautical cat and mouse. Meanwhile, Raffi and Worf uncover a nefarious plot from a vengeful enemy Starfleet has long since forgotten.

With time running out, Picard, Riker and crew must confront the sins of their past and heal fresh wounds, while the Titan, dead in the water, drifts helplessly toward certain destruction within a mysterious space anomaly.

Caught by Starfleet and facing court martial, paranoia grows as Picard struggles to uncover whether a prodigal crewman from his past has returned as an ally – or an enemy hellbent on destroying them all.

Now on the run, Picard and the skeleton crew of the USS Titan must break into Starfleet's most top-secret facility to expose a plot that could destroy the Federation. Picard must turn to the only soul in the galaxy who can help: an old friend.

Crippled, cornered, and out of options, Picard stages a gambit to trap Vadic and reveal her true motive – a gamble that puts the Titan in the crosshairs and forces Picard and Beverly to question every moral code they’ve ever held.

Vadic forces Picard to make an impossible choice: deliver what he can never give... or watch his crew perish. Their only salvation lies in the mind of an old friend and old foe.

A devastating revelation about Jack alters the course of Picard’s life forever – and uncovers a truth that threatens every soul in the Federation. The final battle begins as Picard and his crew race to save the galaxy from annihilation – but not without a gut-wrenching cost.

In a desperate last stand, Jean-Luc Picard and generations of crews both old and new fight together to save the galaxy from the greatest threat they’ve ever faced as the saga of Star Trek: The Next Generation comes to a thrilling, epic conclusion.