J. Jonah Jameson hires Dr. Farley Stillwell who is a raining genius in genetic engineering, to make a new super hero that can match and defeat Spider-Man. With a willing participant, Mac Gargain, they engineer the DNA of a scorpion and him together to form a new hero, The Scorpion. However, when Mac thinks they have turned him into a freak, hero turns to monster and he goes on a rampage. Spider-Man is then forced to step in to stop creation from killing creator.

Harry's father Norman Osborn disappears after an explosion at his chemical plant. Spidey's search for his friend's father one way or another meets with complications. Namely an airborne fiend who calls himself the Green Goblin!

Robbie Robertson is losing his son, Randy, to a gang of thugs lead by Tombstone. When this harder-than-stone hit man tries to use his history with Robbie to kill a story about his new boss, Alicia Silvermane, he runs afoul of Spider-Man. Both discover Robbie's bond with his child and his ethical resolve is mightier.

When Dr. Ohn's Time Dilation Accelerator falls into the wrong hands all the criminal minds of the city vie for the portal technology. Peter and Mary Jane are celebrating Felicia Hardy's engagement to Jason Macendale when they overhear plans for a major heist!

Peter Parker and Mary Jane are finally a couple, but there happiness is short-lived as the Green Goblin, armed with a time distorter and the true identity of Spider-Man, seeks to destroy Spidey, by any means necessary.

Felicia Hardy, now transformed into the Black Cat, is blackmailed into working for Kingpin, until he can replicate more of the "Super Soldier" serum.