Adrian Toomes wants revenge when Norman Osborn attempts to take over his company, Toomes Aeronautical. He becomes the Vulture and immediately kidnaps Norman's son, Harry. Will Spidey be able to rescue Harry from the Vulture's youth stealing talons?

While settling in to her new role as a hero, the Black Cat is captured by Allistair Smythe, now working for Silvermane, who is trapped in the body of a baby. Smythe delivers Spidey an ultimatum: capture the Scorpion or the Vulture within 24 hours or the Black Cat dies...