The Edo period. Daughter of a martial arts dojo, Rin embarks on a journey to take revenge for her slain parents. For her bodyguard on the journey, she has chosen the immortal man Manji, nicknamed the Slayer of Hundreds. Her target is the head of the Ittou-ryu, Kagehisa Anotsu, the man she hates. The adventure of the man who never dies and the girl who's sworn to live for revenge unfolds.

A prostitute approaches Manji as he waits for Rin. Though Manji sees through the prostitutes ruse, he accepts her invitiation. But this woman, 'Makie Otonotachibana', seem to weak to be a warrior of the Ittou-ryu as she claims. After sparing Makie's life, she appears before Manji again with different eyes and hair.