Clark and General Lane are both having a hard time giving Lois room to make her own decisions. Meanwhile, Lana and Sarah have a run-in with an old friend at the diner.

Lois and Clark dig deeper on Bruno Mannheim, starting with his connections to Hob's Bay Medical Center, while Jonathan and Jordan panic at home over Lois' dire diagnosis.

After learning about Bruno and Peia, Clark works to reignite Lois' interest in taking Bruno down; elsewhere, Natalie meets Matteo's parents, with disastrous consequences.