Three years after the Bone Collector ended his career, Detective Lincoln Rhyme teams with NYPD officer Amelia Sachs to investigate a series of murders that suggest the killer's return and an unlikely team is born

Lincoln, Amelia and the team are tasked with tracking down an anonymous bomber, targeting a string of buildings all across Manhattan. Meanwhile, the marriage between The Bone Collector and his wife, Danielle, reaches a terrifying crossroad.