Seventy years later, the state of war between the Lycans and the Vampires remains. The power-hungry Vampire Kraven has seized power from the slumbering Viktor, leaving the Vampires in a state of disarray. Meanwhile, Selene continues her pursuit of the Lycan brothers. It is now the late 1960s, and Selene has returned to Paris in search of her prey that eluded her decades ago. As she hunts the Lycans down, the brothers lay in wait, hoping to avenge the death of one of their own.

It's the year 2012, and the world has become a police state. The war between the Lycans and the Vampires is now known to mankind, and dedicated police forces hunt for vampires with brutal force and at the expense of personal liberty. Selene, now teamed with a Werewolf/Vampire hybrid named Michael Corvin -- a creature that wields the powers of both species -- is continuing her hunt that began more than 100 years ago. She's once again in Paris, tracking down her prey through both advanced technology and good old fashioned detective work. Can she and Michael finally put an end to a pursuit that's lasted more than a century?