Vers la fin des années 70, sur la 54e rue de Manhattan, dans un ancien studio de télévision tombé dans l'abandon, surgit dans la vie nocturne new-yorkaise un lieu qui va vite acquérir le statut international de plus grande boîte de nuit de tous les temps. Le Studio 54, un lieu imaginé par Steve Rubell, un entrepreneur originaire de Brooklyn, devient l'âme et le symbole de son époque. Ce film évoque les grands moments de ce haut lieu des nuits new-yorkaises et toutes les personnalités qui l'ont fréquenté.

A grim police detective embarks on a one-man crusade to track down a depraved sex maniac when a nightclub deejay receives a disturbing series of obscene phone calls. Finding himself getting far too close to the victim for comfort, the hard-boiled cop must track down the unbalanced pervert before he can carry out his sick threats...

After a tragic accident caused by the truck of the middle-aged Carl Lee where a woman dies with a crushed stern, he is arrested and sent to the county jail. His son PJ, who works washing dishes and cleaning tables in a restaurant, feels lost, without financial support to keep his father's house, and is fired from his job and evicted from his house.

Big Town Girls have dating service jobs long enough to learn that a society matron needs a boxer to perform at a party. They talk a waiter into playing the part and a series of accidents and tricks sends him on a boxing career.