Yuji Itadori er en gutt med enorm fysisk styrke, selv om han lever et helt vanlig liv på videregående skole. En dag, for å redde en klassekamerat som har blitt angrepet av forbannelser, spiser han fingeren til Ryomen Sukuna, og tar forbannelsen inn i sin egen sjel. Fra da av deler han en kropp med Ryomen Sukuna. Guidet av den mektigste trollmannen, Satoru Gojo, blir Itadori tatt opp på Tokyo Jujutsu High School, en organisasjon som bekjemper forbannelsene... og slik begynner den heroiske fortellingen om en gutt som ble en forbannelse for å utdrive en forbannelse, et liv han aldri kunne vende tilbake fra.

Kamijo is a student in Academy City, where people use science to develop supernatural abilities. The guy’s got a lot of heart – luckily for a young nun named Index. She’s on the run from a sorcery society that covets the astonishing 103,000 volumes of magical knowledge stored in her memory. When Index stumbles into Kamijo’s life, she finds a faithful friend and protector, and while Kamijo’s easily the weakest kid in Academy City, he’s got something else going for him: the Imagine Breaker, an unexplainable power stored in his right hand that negates the powers of others. With scientists and sorcerers attacking from all sides, the Imagine Breaker will definitely come in handy – but it’s Kamijo’s loyalty to Index that will be his greatest weapon in the fight to keep her safe.

Psychic investigator Subaru Sumeragi is hot on the tail of a serial killer who seems to have some supernatural powers of his own. When Subaru encounters a young girl placing a curse on his suspect, the mystery deepens. The body count continues to rise, and Subaru must solve the case quickly, or he may become the killer’s next target!