故事發生在第三季的9個月後，接二連三源自顛倒世界的離奇死亡事件引發霍金斯居民的恐慌。

1986年3月，來自顛倒世界的威可那連續殺害數名高中生，這使分道揚鑣的夥伴必須面對這場威脅。同時喬絲·拜爾斯和莫瑞·鮑曼試圖幫助被囚禁在俄羅斯堪察加半島監獄中的吉姆·哈普逃亡。本季的劇情共分為三個不同的視角敘述。

位於霍金斯的視角以達斯汀、麥克絲、艾瑞卡、史帝夫、南西、蘿蘋和路卡斯為主角。達斯汀和朋友們加入了龍與地下城社團「地獄火俱樂部」。團長艾迪親眼目睹籃球校隊隊長傑森的女友克莉希遭離奇殺害，卻成為頭號嫌疑人，並被傑森等人追趕，認為艾迪在撒旦的幫助下獲得殺死克莉希的力量。在連續數名青少年離奇死亡後。夥伴們意識到此次連環殺人事件的主謀是來自顛倒世界的強大生物威可那。

位於加州的視角，以搬至新家的11號、威爾、喬納森及前來探望的麥克為主角。由於霍金斯面臨新的威脅，11號被布倫納和歐文斯帶到一個秘密實驗室以恢復她的超能力，另一邊的麥克、威爾、喬納森和他的朋友阿蓋啟程尋找11號的下落。

以喬絲和莫瑞為主的視角，講述他們得知哈普倖存的消息，於是帶著贖金前去解救。而囚禁在俄國堪察加半島的哈普，要與被俄國人俘虜的魔神戰鬥。

In attempt to find a non-violent alternative for reducing Hell's overpopulation, the daughter of Lucifer opens a rehabilitation hotel that offers a group of misfit demons a chance at redemption.

戰爭結束了。薇爾莉特·艾佛加登需要找份工作。曾經心理受創且外表冷漠的她，接下寫信員的工作，藉此了解自己和自己的過去。

The vampire Angel, cursed with a soul, moves to Los Angeles and aids people with supernatural-related problems while questing for his own redemption. A spin-off from Buffy the Vampire Slayer.

France, 1815. Jean Valjean, a common thief, is released from prison after having lived a hell in life for 19 years, but a small mistake puts the law again on his trail. Ruthless Inspector Javert pursues him thorough years, driven by a twisted sense of justice, while Valjean reforms himself, thrives and dedicates his life to good deeds. In 1832, while the revolution ravages the streets of Paris, Valjean and Javert cross their paths for the last time.

A dream of falling from the sky...and then birth. Rakka is born from a large cocoon into the Old Home, greeted by a group of females with small wings on their backs and shining halos above their heads. Soon Rakka’s own wings grow, a halo is placed on her head and she is told that she must work in the nearby town of Grie. She soon realizes that the town and the entire world they live in are confined behind the Wall, a tall, impenetrable wall that none except the mysterious Toga are allowed to exit.

Grace Hanadarko is a tormented, fast-living Oklahoma City police detective who, despite having an excellent career in solving crimes, takes self-destruction to new heights. After seeing tremendous tragedy, both professionally and personally, Grace reaches a turning point one night and meets a rough-hewn angel with a similar past who wants to help lead her back to the right path.

Romance blossoms between a single mom and a womanizing bad boy.

四個啟發自台灣真實案件的故事。一起火車出軌翻覆，造成保險調查員邱文青的丈夫趙彥傑重傷昏迷，而唯一的死者林冬山生前買下鉅額保險，讓辦案檢察官于晨朗懷疑火車翻覆可能並非意外，面對重重謎團，邱文青與于晨朗攜手調查，究竟鐵路出軌是意外還是兇手真有其人？老刑警王英民在生日當天接獲案發通報，趕到國小案發現場，死者竟是女兒王昱萱。王昱萱在停車場慘遭侵犯，兇手倉皇逃離，僅留下被破壞的現場與謎樣的指紋，而王昱萱的學生林善亦卻意外目睹一切。劍走偏鋒的記者李博勝到監獄專訪叱吒風雲的幫派份子沈昌戎，這位江湖上聞風喪膽的冷血殺手，雖承認大部分罪狀，卻始終否認殺害葉宅一家五口，面對人心真假難辨，李博勝要如何挖出真相？一場江湖腥風血雨即將引爆。通緝犯阿傑為逃亡找上軍中服役的弟弟阿成，阿成讓他暫住廢棄軍營。隔日，一名男童在營區慘遭殺害，種種嫌疑竟都指向阿成。阿傑為了救阿成，在黑白兩道追殺之下限時揪出真兇。

This dark medical drama examines the meaning of human life, centring on a team of unidentified black-market doctors who undertake any kind of surgery with superhuman surgical skills and exorbitant medical expenses. Hazama Eisuke, also known as "Ace", is a genius surgeon who works as a patissier during the day. He has an operating room equipped with the latest equipment in the basement of his patisserie, where he performs surgeries on patients who have been abandoned by others. Shimoyamada Jo, also known as "Joker", is a brilliant international lawyer and a negotiator with patients.

After getting ousted from his job in the NCAA for throwing a chair at a referee, a hothead men’s basketball coach Marvyn Korn must take a job at Westbrook School for Girls, a private all-girls high school, in an effort to redeem what's left of his career and reputation.

In 1974, in the quiet suburb of Sainte-Foy, two discontented couples bring their kids to summer camp. Once home, they must face the pitiful state their marriages are in. Unable to deal with their problems, they become the most infamous criminals in the history of organized crime in Quebec City.

Tamás and Rajmund grew up in a children's home, but their lives took a completely different direction after that. Tamás became an outcast from a police officer, while Rajmund made his fortune as a criminal. They both fall in love with the same woman. Rajmund doesn't take kindly to this, so he does everything to drive Tamás out of the city. A story about love, family and redemption...

A tale of secrets and scandals set in 1840s London. When the Trenchards accept an invitation to the now legendary ball hosted by the Duchess of Richmond on the fateful evening of the Battle of Waterloo, it sets in motion a series of events that will have consequences for decades to come as secrets unravel behind the porticoed doors of London’s grandest postcode.

To carry out her dad's wish and discover her roots, Dai Tian-qing embarks on a journey around Taiwan and finds love and redemption on the way.

Eiri works at his uncle's antique shop, and one day stumbles across a glass. Upon touching the glass, he receives visions from what he finds out to be a girl, Cossette, haunting the glass. She's been searching for over 250 years for someone who could see her, and now she needs his help.

In the crime-ridden, mafia-governed city of Ergastulum, Worick and Nicolas are two “handymen” known as “Benriya” who would take any dirty job from either police or mafia — for a good price. After an assignment from police the two met and later joined by Alex, a former prostitute who got interested in the mysterious background of the team, in particular of Nicolas’ abilities.

Darnell "Superchef" Ferguson invites superstar chefs to settle their disputes in a one dish, winner-takes-all heavyweight battle. The victors leave with $10,000, a prized knife from the losing chef's knife roll and bragging rights for life!

War looms over the kingdom of Neunatia, where two young women are both burdened and blessed by the power of song.

Detective Gido Kennin (Tanaka Kei) specialises in reinvestigations, and is the most shunned and loathed person at the Tokyo Metropolitan Police Department. He carries around a name card with no department written on it and takes pleasure in uncovering cases where the police created false charges. Gido reveals the negligence of the police such as mistakes in initial investigations and cover ups, reconsidering the testimonies and evidence from these cases to discover the real criminals. He hates it if people escape punishment and in order to prevent this from happening, he makes all other sacrifices. It is said that no one will be happy after Gido’s investigations, and this has earned him the nickname “grim reaper”.