MegaTokyo 2033: Tokyo was left flattened as a result from a great earthquake.

A new city, MegaTokyo, was then recreated due in no small part from the aid of a multi-million dollar company, Genom Corp. Genom created and mass-produced biomechanical creatures called Boomers to aid in the restoration of MegaTokyo.

When the Boomers began to run out of control, the ADPolice at first tried to stop them, but they proved to be far more difficult to deal with than was first imagined.

Under the ever looming Boomer threat, a group of four girls from varying degrees of society banded together. Calling themselves The Knight Sabers, they were the only ones with enough firepower and resourcefullness to defend the fledgling MegaTokyo from Genom and it's berserk Boomers.

A great warrior is displaced to the distant future by the evil shape-shifting wizard Aku. The world has become a bleak place under the rule of Aku, segregated into fantastic tribes and ruled by Aku's evil robot warlords. Jack travels this foreign landscape in search of a time portal that can return him to his home time so he can "undo the future that is Aku!".

Radnja je smještena u blisku budućnost u kojoj vanzemaljci Votanci dolaze na Zemlju nakon što je uništen njihov sunčev sustav. Zemljani ih baš i nisu spremni primiti pa započinje rat koji, uslijed uništavanja i teraformacije, u potpunosti mijenja sliku Zemlje. Nakon desetljeća rata, proglašeno je primirje i dojučerašnji neprijatelji moraju otkriti način kako živjeti zajedno, u sada stranom svijetu. Serija se većinom vrti oko Jeba Nolana koji se nakon rata vraća u svoj rodni St. Louis, sada Defiance, gdje postaje šerif...