重案夢幻組馬加斯（馬田羅倫斯飾）及米高（韋史密夫飾）闊別八年後再度聚首，被調派往邁阿密調查毒品活動，並設法搗破販毒集團的地下交易。調查期間，這對最佳拍檔卻出現了不少磨擦，不過，最令馬加斯看不過眼的是米高竟然情陷他的妹妹斯迪。米高是個出名的花花公子，馬加斯最疼錫這個妹妹，見到她與這個花花公子搭上，他怒不可遏，大大影響這個夢幻組的合作關係。到底這對出生入的拍檔最終能否公私分明，合力破案？
釋囚金馬倫（基治飾）正準備乘機飛往與妻女團聚，卻乘上一滿載頭號通緝犯的特別航機，並遇上罪犯首領「細菌」（尊馬高域治飾）策動劫機行動，金馬倫亦被捲入劫機旋渦中！金馬倫唯有力戰悍匪，阻止飛機衝進繁盛的拉斯維加斯。同時，政府密探（尊古錫古飾）亦正力挽狂瀾，阻止瘋狂的執法上司摧毀航機！
年過八旬的窮困孤獨老人Earl Stone(奇連伊士活 飾)面對物業即將被拍賣，他接到一份簡單的駕駛工作，不知情地簽下合同，為墨西哥販毒集團運毒。他做得如魚得水，出貨量節節上升，直屬於一個大毒梟。這不只令毒梟緊盯著Earl的一舉一動，他亦成為了美國緝毒局(DEA)探員Colin Bates(畢列谷巴 飾)之頭號目標。雖然Earl的財政問題得以解決，但他開始為犯下的過錯後悔，試圖希望改正。然而Colin矢志不移，要對Earl窮追不捨…
總統的朋友遭人殺害，中情局副局長傑克·萊恩在不知不覺中捲入了對抗哥倫比亞販毒集團的非法戰爭。
一位是海軍情報員，另一位則是美國緝毒局探員。這兩名特勤幹員各自執行臥底行動，對抗販毒集團，卻在情況嚴重出錯後攜手合作。
巴利薛爾 (湯告魯斯 飾) 飛行技術超卓，表面上是民航機師，暗地裡走私違禁品。一天他被中情局找上，要求協助收集情報，繼而運送違禁品。其間巴利認識了哥倫比亞大毒梟，大茶飯越搞越大，更引起緝毒局和白宮注意！不甘平凡、喜歡踏鋼線的巴利，究竟能否成功瞞天過海，玩轉全球黑白道？
A Molokai-based civilian pilot and an undercover DEA agent intercept a delivery of diamonds intended for druglord Seth Romero. Seth, his henchmen, and other island undesirables launch a full-scale assault on the duo. If they're going to survive, they'll need the help of agent Rowdy Abilene and his partner/kickboxing expert Jade.
Pot growers Ben and Chon face off against the Mexican drug cartel who kidnapped their shared girlfriend.
A semi-retired special ops assassin and a DEA agent cross paths on separate missions to stop a cyber terrorist organization that has built a dangerous machine threatening to attack the power grid and bring catastrophe to the world.
Philosophical twenty-something Ross Ulbricht creates Silk Road, a dark net website that sells drugs, while DEA agent Rick Bowden goes undercover to bring him down.
Ten easy steps show you how to make money from drugs, featuring a series of interviews with drug dealers, prison employees, and lobbyists arguing for tougher drug laws.
Shane Tanner, the son of a legendary cooler named Dalton, learns that his uncle Nate got beat up by a group of men because he doesn't want to sell his bar, The Black Pelican, to a bunch of drug dealers. To help out his uncle, Shane teams up with local school teacher Beau Hampton, who is a regular at the Black Pelican, and takes down the baddies.
In the frenetic underbelly of Los Angeles, Agent Maxwell closes in on an international cocaine smuggling operation run by criminal mastermind Vincent Camastra. When Agent Beverly Royce goes undercover with the drug dealers and finds herself deeper then she can handle - the case becomes personal for Maxwell who has to combat ruthless killers and dirty cops in an all-out action filled finale to bring the criminals to justice.
Spurred on by the death of his drug-addicted sister at the hands of ruthless narcotics kingpin Frank McNally, U.S. drug enforcement agent Charles Sturgis embarks on an investigation that takes him from New York to London, Lisbon, Rome, Naples and finally Athens in pursuit of McNally's shapely associate, Gina Broger.
Caracas, Venezuela. 1982. Ryan of the DEA and Carlos the PTJ join forces to stop the most dangerous drug lord of the country, Disco Herrera.