Miles Morales regressa para o próximo capítulo da saga Universo-Aranha, vencedora deum Óscar. Uma aventura épica que transportará o amigo da vizinhançade Brooklyn, Homem-Aranha, através do Multiverso para unir forças com Gwen Stacy euma nova equipa de Pessoas-Aranha. Miles, Gwen e esta equipa irão enfrentar um vilão muito mais poderoso do que qualquer outro antes encontrado.
Peter Parker é um adolescente que tenta conciliar o liceu com as fantásticas crises sobre-humanas do seu alter-ego, o Homem-Aranha.
Ross Jennings é um médico que vai morar, com a sua família, numa pequena cidade do interior da Califórnia. Quando todos os seus pacientes começam a morrer misteriosamente, ele começa a suspeitar que as mortes tenham sido provocadas por aranhas, posto que todas exibem as marcas de mordidas deste insecto.
Investigating the mysterious deaths of a number of farm animals, vet Rack Hansen discovers that his town lies in the path of hordes of migrating tarantulas. Before he can take action, the streets are overrun by killer spiders, trapping a small group of townsfolk in a remote hotel.
When a team of backpackers sets out to explore the Indian jungles, one of them is bitten by a poisonous spider and killed.
A doctor is driven into an investigation of sinister goings-on at a horse race track by his mystery writer ex-wife.
The Iron Cross Army are sabotaging oil-tankers with the help of their monster, the Sea-Devil, a semi-mechanical anthropomorphic swordfish with an ability to shoot torpedoes from its mouth. Spiderman employs the help of the interpol agent Juzo Mamiya to help him stop the Iron Cross Army.
An airplane carring coffee beans from South America has some unpleasant stowaways: a hoard of tarantulas which overcome the pilots as the airplane is flying over an orange-producing town in California. The airplane crashes, and the unlucky inhabitants of the town release the poisonous spiders into their midst. Once the town's officials discover that the tarantulas are responsible for several deaths, the tarantulas have already descended upon the town's only orange-processing factory. The town's citizens risk their lives to remove the tarantulas from the factory while the poisonous pests are rendered motionless by the transmitted sound of buzzing bees