邁爾斯摩拉斯將再度回歸獲得奧斯卡金像獎的《蜘蛛人：新宇宙》的續集篇章，這次這位紐約布魯克林的全職社區英雄，將與女蜘蛛人關史黛西聯手穿梭多元宇宙，展開一段史詩般的冒險。但是當他發現其他蜘蛛人對於自身存在的執著，而且在面對威脅意見紛紛時，傷痕累累的邁爾斯必須找到自己作為一位超級英雄的定位，並且拯救他所愛的人。
【蜘蛛人：驚奇再起】內容描述孤兒彼 得帕克〈安德魯加菲爾德 飾〉從小寄居在梅姨(莎莉費爾德 飾)與班叔(馬丁辛 飾)家中，內向害羞的他在校雖常被欺負，但隨著帕克愛上學校的風 雲人物關史黛西〈艾瑪史東 飾〉後，兩小無猜的純純初戀讓他孤獨的生命 找到希望。當帕克在班叔家中發現父親留下的一個神祕包包後，他開始尋 找當年雙親離奇失蹤的線索，並因此找上父親當年實驗室的夥伴康納博士(瑞斯伊凡飾)。在一次意外遭蜘蛛咬傷後，帕克突然擁有異於常人的飛天攀爬能力，成為媒體與社會討論撻伐的神秘人物：蜘蛛人。蜘蛛人的秘密讓 帕克必須在女友及她擔任警察局長的父親面前隱藏身分，而當他發現 康納博士的真實身分其實是大反派蜥蜴博士後，帕克該如何面對外界對蜘蛛人身份與能力的質疑，不顧一切挺身而出，拯救紐約市民免於災難？
A large spider from the jungles of South America is accidentally transported in a crate with a dead body to America where it mates with a local spider. Soon after, the residents of a small California town disappear as the result of spider bites from the deadly spider offspring. It's up to a couple of doctors with the help of an insect exterminator to annihilate these eight legged freaks.
Investigating the mysterious deaths of a number of farm animals, vet Rack Hansen discovers that his town lies in the path of hordes of migrating tarantulas. Before he can take action, the streets are overrun by killer spiders, trapping a small group of townsfolk in a remote hotel.
When a team of backpackers sets out to explore the Indian jungles, one of them is bitten by a poisonous spider and killed.
A doctor is driven into an investigation of sinister goings-on at a horse race track by his mystery writer ex-wife.
The Iron Cross Army are sabotaging oil-tankers with the help of their monster, the Sea-Devil, a semi-mechanical anthropomorphic swordfish with an ability to shoot torpedoes from its mouth. Spiderman employs the help of the interpol agent Juzo Mamiya to help him stop the Iron Cross Army.
An airplane carring coffee beans from South America has some unpleasant stowaways: a hoard of tarantulas which overcome the pilots as the airplane is flying over an orange-producing town in California. The airplane crashes, and the unlucky inhabitants of the town release the poisonous spiders into their midst. Once the town's officials discover that the tarantulas are responsible for several deaths, the tarantulas have already descended upon the town's only orange-processing factory. The town's citizens risk their lives to remove the tarantulas from the factory while the poisonous pests are rendered motionless by the transmitted sound of buzzing bees