The anime takes place on the screw-shaped island country of Nejigajima and follows the two "Bokyabots" Hebot and the Yurui Prince Nejiru as they collect different "Bokya Neji" screws. When the Bokyabots wear the Bokya Neji screws on their heads, they're able to compete in "Bokya Battles," battles for who can think up and tell the best jokes.

In Sapporo's North 24th neighborhood, five stations away from the Susukino business district, a bar's proprietor, junior proprietor, odd regular customers, and its share of walk-ins recount their strange lives.

Have issues with depression, erectile disfunction, dementia, or even with your love life? Don't worry, as the psychologist Ryou and his nurse Asuna will seriously try to help you understand these mental disorders all while laughing!