距離地球極為遙遠，五個月亮照耀著的灼熱星球–荒漠之星。倖存的人類依賴能夠從零產生各種物質的生態動力爐「PLANT」，於異形生物蠢蠢欲動的荒涼大地，艱辛度日。在這個嚴峻的世界中，威席・史坦畢特是位懸賞金額價值 600 萬，傳聞碰上他必逢災難因而被人冠上「人形颱風」的稱號的神槍手。新進媒體人梅麗魯・斯菲與酒鬼資深記者羅伯特・德尼拉共同調查「人形颱風」這個重大獨家新聞，然而卻找到了一位身穿深紅色大衣的槍手，他的原則是「絕不殺人」，來去如風，比誰都還要爛好人…

Trigun takes place in the distant future on a desert planet. Vash the Stampede is a gunfighter with a legend so ruthless he has a $$60,000,000,000 bounty on his head. Entire towns evacuate at the rumor of his arrival. But the real Vash the Stampede, the enigmatic and conflicted lead character, is more heroic, even though he usually acts like a complete idiot.