While running from a drug deal gone bad, Mike Ross, a brilliant young college-dropout, slips into a job interview with one of New York City's best legal closers, Harvey Specter. Tired of cookie-cutter law school grads, Harvey takes a gamble by hiring Mike on the spot after he recognizes his raw talent and photographic memory.

Former Syracuse, New York, police detective Carrie Wells has hyperthymesia, a rare medical condition that gives her the ability to visually remember everything. She reluctantly joins the New York City Police Department's Queens homicide unit after her former boyfriend and partner asks for help with solving a case. The move allows her to try to find out the one thing she has been unable to remember, which is what happened the day her sister was murdered.

Fun-loving San Francisco Police Department investigator Nash Bridges is part of the elite Special Investigations Unit. He tackles crime using his keen sense of humor and charm. Joe Dominguez comes out of retirement to become Bridges' wisecracking yet more rule-abiding partner.