一節無人駕駛的巨型高速火車因故失速的向前衝，車上載滿了有毒物質，行進的過程中將會帶來毀滅性的災害，來自不同單位的警消人員都意圖阻擋，但都紛紛失敗，…一位退休的工程師(丹佐華盛頓飾)以及年輕的駕駛員(克里斯潘恩飾)登上了另一節在同樣路徑上的火車，必須在100分鐘內想出辦法在高速火車抵達人口最多的大城市之前將它停住，他們能否即時阻擋這台恐怖的毀滅列車呢？

故事主角是一個生活在30年代法國巴黎的12歲孤兒雨果．卡柏瑞，他住在火車站的高牆內，在熙攘的人群中穿梭，藏身于大鐘後方，冷眼觀察來往過客，隱姓埋名，滿腦子秘密。 他的父親在修理博物館機器人的過程中離奇死去，為了找出父親留給他的資訊，雨果也開始修理這個機器人，然而這卻引出更複雜、驚人的秘密，雨果的命運就此改變。 薩夏拜倫柯恩飾演的警察以誇張的表情和聲音成為最有看點的角色，這個警察一開始是個凶狠的獨裁者，專門追捕流浪兒童，又因在戰場上受過傷而很自卑孤獨。薩夏說：「一開始看到這個角色我一直在想為什麼他這麼喜歡追捕流浪兒童，後來我們商討決定把他塑造成戰場上受過身體和心靈創傷的人，因此他才會有扭曲和複雜的人格。」

11-year-old gaming enthusiast Hedvig finds her life turned upside down when she is forced to replace her father as the town’s superhero much earlier than expected. But Hedvig is no superhero, and the challenges are far greater than her coaching father anticipated.

NATO operative Jacques Kristoff (Jean-Claude Van Damme) is summoned into action—on his birthday, no less—to track down Galina Konstantin (Laura Harring), who has stolen an extremely valuable and dangerous top-secret container from the Slovakian Government. Finding Galina doesn't take long, and Jacques must wrap up the mission by returning Galina and the contraband to his superiors by train. Things seem to be going smoothly as Jacques and Galina board the train posing as a couple, but soon all hell breaks loose.

Comedy in which a bungling railway worker is given the job of stationmaster at a rundown station in rural Ireland, where his sidekicks are a toothless old gaffer and a portly young loudmouth. Hilarious adventures ensue, including a locomotive chase after gunrunners make off with a train.

A deranged engineer, bent on revenge for the deaths of his wife and daughter, sets two passenger trains on a collision course, and con-man William Shatner puts his life on the line to ward off the crash.

A gang of thieves gather at a safe house following a robbery, but a detective is on their trail.

Ruth Raymond works on the telephone switchboard of a large NYC office building. One day, a private detective informs her that she is actually the daughter of railroad tycoon Luke Carson, and that she had been kidnapped as a baby 14 years ago by Luke's vindictive brother Elwood, and placed with strangers.

On the night express train from Los Angeles to San Francisco everyone’s a suspect when a jewelry magnate is found stabbed to death and an escaped killer is feared on board. It’s up to newspaper reporter Jimmy Hawley (Ben Lyon) to unravel the secrets of the motley group of passengers and find the killer before he strikes again in this tense and atmospheric whodunit.

Virginia Craig will become super-wealthy and gain sole control of her factory, unless insubordinate schemers can trick her into marrying one of their clique. Unfortunately for them, she loves Monty, one of her employees. When the schemers' plot is discovered, a chase starts away from the factory and onto a runaway train.

A group of skiers are trapped inside a runaway train hurtling down a mountainside.

The gang is playing around the railroad station, and Joe and Chubby's father, an engineer, lectures against the kids playing in such a dangerous area. True to his word, after Joe and Chubby's father leaves, a crazy man starts a train with most of the kids on it, save for Farina who is nearly run over several times.

Once Farina manages to climb aboard himself, the kids attempt to stop the runaway locomotive, but have no luck until the engine crashes into a grocery truck. As it turns out, however, the entire incident is revealed to be a dream Farina had as Joe and Chubby's father lectured the kids about rail-yard safety.

In Lisbon, a German married couple get aboard the legendary tramway no 28.