Totally Spies! depicts three girlfriends 'with an attitude' who have to cope with their daily lives at high school as well as the unpredictable pressures of international espionage. They confront the most intimidating - and demented - of villains, each with their own special agenda for demonic, global rude behavior.

Hayami Honoka works in the sales department for a major consumer electronics company. She is excellent at her job and is respected by her colleagues. She seems like a clean freak at work and her colleagues think she is a perfect person to marry. But, in her private life, her home is a complete mess. Things there are unorganized and dirty. On the flip side, when she arrives at work, she looks perfect.

Meanwhile, Yamamoto Chihiro is Hayami Honoka's co-worker in the same department. He joined the company 3 years after Hayami Honoka. When he was a child, Yamamoto Chihiro and his two brothers did the housework at his home, while his mother was busy with her job. Because of this, Yamamoto Chihiro is excellent at doing household chores. Due to a case, he happens to learn that Hayami Honoka's home is a mess. He begins to stay with Hayami Honoka on the condition of doing the house work.

The tragic story of the many lives of Father Dinis, his dark origins and his pious works, and the different fates of all those who, trapped in a sinister web of love, hate and crime, cross paths with him through years of adventure and misfortune in the convulsed Europe of the late 18th and early 19th centuries. (A longer television version of the film of the same name, released in 2010.)