Denizens of Lux have come to call it "The City" and treat it as a sentient force. Three factions vie for control of the city: the Organo, a strictly professional conglomerate with ties to the criminal underworld in the prosthetics business; the Union, a fanatical populist group interfering with Organo's affairs; and Racan, a marauding group of Texhnolyzed youths.

Ten years after the demise of Precrime, crime-solving is different and justice leans more on sophisticated and trusted technology than on the instincts of the precogs—individuals who able to see the future. In Washington, D.C., a man haunted by the future and a cop haunted by her past race to stop the worst crimes of the year 2065 before they happen.

Rin Asogi is an immortal private detective with a thirst for vodka and a talent for attracting things that go bump in the night. In a series of nightmarish vignettes spanning sixty-five years, Rin's lush body is sadistically pierced, blown up, and mulched to a bloody pulp. The fiend behind her tortured existence is Apos, an eternal being obsessed with sacrificing Rin to Yggdrasil, the tree of all life. While Rin struggles to unravel the secrets of her endless agony, Apos lurks in the shadows, eager to tear into her ripe body and devour the memories of her countless lives. Rin's no stranger to the realm of the dead, but her next visit could last forever.