闊別5年，由環球影片 榮譽發行、麥迪文 主演、全球票房收益近10億美元的《叛諜追擊》系列將於8月強勢回歸！全新演員陣容加上原班幕後精英合力打造《叛諜追擊4：機密逃殺》！電影延續改編自羅拔盧林 原著小說及前三集劇情，由謝洛美維納 飾演的故事主人翁將會捲入一個因前三集而衍生的致命漩渦當中，究竟所為何事？他又將如何見招拆招？《叛諜追擊4：機密逃殺》 將由《敵對同謀》、《叛諜追擊》系列的金像提名編劇東尼格萊 執導，更與《鐵甲鋼拳》丹格萊 第一次兄弟幫上陣編劇，加上由兩位金像影帝提名男星《拆彈雄心》謝洛美維納 和《野獸良民》愛德華諾頓、金像女配角得主《無國界追兇》麗素慧絲、荷里活上位魅力型男《極速罪駕》奧斯卡依撒 等耳目一新的強大陣容擔綱演出，誓必再次震懾全球！

By coincidence rather than by design, the Swiss chemist Albert Hofmann makes a sensational discovery in the spring of 1943. He realizes that he is dealing with a powerful molecule that will have an impact that reaches far beyond the scientific world. THE SUBSTANCE is an investigation into our troubled relationship with LSD, told from its beginnings to today.

A drug trafficking gang kidnaps the son of a pharmaceutical tycoon. The young man is attracted to one of the girls in the gang, which they will take advantage of to earn his trust. The goal: get their hands on heroin and cocaine from the father's company's laboratories.