一份能夠挑起全球核戰的密件被盜，逼令藏身監獄的伊頓 (湯告魯斯 飾) 突破警戒重出江湖，可惜他在調查過程中慘被設計陷害，成為炸毀俄羅斯克里姆林宮的代罪羔羊，為此美國政府更執行了「鬼影約章」，令整支職業特工隊頓成棄卒！為了查出真相及挽回清白，伊頓與幾位戰友在毫無支援下作出絕地反擊，以尖端裝備和超凡膽色在繁華街道、摩天大廈甚至巨大的沙塵暴中，跟幕後黑手展開連場鬥智鬥力的埋身激戰！

In the jungles of Ecuador, blood taints the waters. A multinational conglomerate's unholy alliance with a bloodthirsty military regime has resulted in a massacre. Only the rebel Francisco Franco and his determined wife Mia can prove the truth. To settle a personal debt, former CIA agent Jack Begosian takes on the freelance assignment to rescue Francisco and risks everything in a brutal battle to expose the cover-up.

當秘密探員們的身份遭到洩露，倒楣的史麥斯與能幹的特務 99 合作，以阻止邪惡的恐佈組織的行動。