La historia de Los Minions se remonta al principio de los tiempos. Empezaron siendo organismos amarillos unicelulares que evolucionaron a través del tiempo, poniéndose siempre al servicio de los amos más despreciables. Ante su incapacidad para mantener a esos amos – desde el T. Rex a Napoleón –, los Minions acaban encontrándose solos y caen en una profunda depresión. Sin embargo, uno de ellos, llamado Kevin, tiene un plan. Acompañado por el rebelde Stuart y el adorable Bob, emprende un emocionante viaje para conseguir una jefa a quien servir, la terrible Scarlet Overkill. Pasarán de la helada Antártida, a la ciudad de Nueva York en los años sesenta, para acabar en el Londres de la misma época, donde deberán enfrentarse al mayor reto hasta la fecha: salvar a la raza Minion de la aniquilación.
Cuando Superman y el resto de la Liga de la Justicia son secuestrados, Krypto debe convencer a una banda de refugiados (Ace el sabueso, PB el minicerdo, Merton la tortuga y Chip la ardilla) a dominar sus propios poderes recién descubiertos y ayudarlo a rescatar a los superhéroes.
It is written among the limitless constellations of the celestial heavens, and in the depths of the emerald seas, and upon every grain of sand in the vast deserts, that the world which we see is an outward and visible dream, of an inward and invisible reality ... Once upon a time there was a golden city. In the center of the golden city, atop the tallest minaret, were three golden balls. The ancients had prophesied that if the three golden balls were ever taken away, harmony would yield to discord, and the city would fall to destruction and death. But... the mystics had also foretold that the city might be saved by the simplest soul with the smallest and simplest of things. In the city there dwelt a lowly shoemaker, who was known as Tack the Cobbler. Also in the city... existed a Thief, who shall be... nameless.
Mantis Commander and his minions try their best to be the bad guys they think they are.
After being cast into the shadows, the villainous organization known as "Limbo" rises from the darkness. Led by the scourge Doomfist, they seek to bring about a world of change. But a rag-tag group of heroes bands together to oppose the darkness.