When his former secretary is accused of a murder, Perry Mason gives up a judgeship to defend her.
A painter, believed to be dead, returns to make allegations that a gallery owner is selling counterfeits of his work. Later, the artist is murdered.
The chief suspects in the murder of an author are the numerous colleagues whom he continuously plagiarized.
A woman suddenly disappears after an early morning walk, and her husband is accused of murder.
Anthony Caruso, an old friend of Perry Mason, comes to Denver on the request of Dee Morrison. She's married to famed photographer David Morrison, who wants to shoot a photo featuring his former models. The tricky thing is that all of his former models are also his former wives. But Dee knows Anthony can convince them to do it which he does. And David shoots them. Later Dee catches David it what appears to be in an inappropriate situation with his assistant. They have an argument and she leaves. Later David is found dead and she's arrested and Anthony defends her. And he suspects it could have been one of the wives
A gangster who has commited all kinds of crimes is accused to have killed his wife. As he was not the murderer in this case Perry Mason intents to find the killer...
Mason defends a man he had sentenced to prison when he was an appellate-court judge. Now, 18 months after the sentencing, a new witness turns up to prove the man's innocence. Mason steps in to defend the man.
A priest is murdered and the main suspect is a nun.
Perry must defend the husband of an old flame from a murder charge.
The owner of a cosmetics company is unveiling a new cream which she claims she's been using. She's been keeping her age a secret and now reveals that she's 60 and owes her appearance to the cream. She's later killed and the formula missing. Her husband is arrested and Perry defends him.
A Bishop from Australia comes to Perry to ask him to take a case of a woman wrongly accused of manslaughter 22 years before. The case would involve the wealthy Mr. Brownley and the fact that his alleged granddaughter may be an imposter. With that, the Bishop leaves and is clubbed in his hotel room. Soon after, he leaves on a boat and Perry meets the woman - Ida Gilbert. Perry goes to see Mr. Brownley, but gets nowhere. Later that night, Brownley is to meet Ida, but he is shot by a woman who drops Ida's gun. Ida is arrested for the murder of Mr. Brownley and Perry gets involved.
Perry investigates the murder of a former madam and uncovers a multimillion dollar banking fraud in the process.
Perry Mason is invited to the marriage of the daughter of an old friend of his. But after the ceremony the uncle of the bride is dead. Certainly this is a case for Perry Mason.
David Katz is a world famous magician and he comes to Denver with his group to perform for a charity gala for disabled children. Also there is Perry and Della as all three are supporters of the charity. Kate Ford, an assistant with an arrogant attitude, tells David that she is, from now on, going to do an illusion in which an assistant is raised in a glass coffin only to disappear when the coffin is opened up in the air (while the assistant climbs out before the coffin is raised.) After a one night stand with David, Kate is pregnant and she blackmails David with this. David and his wife Judy can't have children so that comes as a double blow to them. However Kate, with her attitude, creates much hatred at her from the rest of the group. At the gala, the glass coffin is raised but when it opens Kate's dead body falls to the ground - strangled.
Perry and Della are finally married by his old friend, Judge Mary. They plan to go on a honeymoon, but before it can start, Perry is retained by a woman with a gun and $5000.
Lawyer Perry Mason is summoned to the Laxter mansion in the dead of night to write granddaughter Wilma out of invalid Peter Laxter's will, to keep her from marrying suspected fortune hunter Doug. Peter dies in a mysterious fire and Laxter's two grandsons, Sam Laxter and Frank Oafley, inherit his estate on the condition old caretaker Schuster and his cat Clinker are kept on. When cat-hating Sam threatens Clinker, Perry steps in and learns Laxter's death was suspicious and the family fortune and diamonds are missing. Schuster's found dead in his basement apartment, Laxter's nurse Louise is murdered with Schuster's crutch, and circumstantial evidence brings Doug to trial for Louise's death. Mason's investigation produces a surprise witness who turns the trial around. Written by Sister Grimm
Sleazy talk show host Ted Mayne writes a tell-all book, which enrages and embarrasses several very prominent women. One of them, actress Roxanne Shield, loses her composure during an interview and winds up making a televised death threat. Of course, when Ted is murdered, she is arrested. Witnesses claim they saw Roxanne outside his apartment that night and police later find the murder weapon in her car. Renowned defence attorney Perry Mason accepts the challenge of defending her in court.
On the set of a popular daytime soap opera 'Mile High', actress Kris Buckner is being forced off by co-star Mark Stratton. When she says that she'll 'kill him before she leaves the show', she makes herself the prime suspect when Stratton is murdered by someone poisoning him. As an old friend, Perry Mason comes to the help of Kris and agrees to defend her. Meanwhile Ken goes in search of information with the help of fan of the show.
Perry Mason ventures to Paris to defend a U.S. Marine Corps Captain accused of murdering a man suspected of being a Nazi SS Officer.
After giving the District Attorney another stinging defeat, Perry plans to take a vacation in China. That is, he was, until Rhoda, his old flame, meets him at a restaurant. It seems that her husband Moxley, who had been allegedly dead for four years, is alive and demanding money as she has married into wealth. The case escalates when the police find the body of Moxley and charge her with the murder.