A young woman from Las Vegas wants Perry Mason to defend her father.
Perry Mason defends the husband of a famous rock singer who was found being killed after having had a tremendous discussion with her husband and her manager.
A priest is murdered and the main suspect is a nun.
Perry is at TV station "KGGY" to be interviewed but thanks to the interference of main anchor-person Brett Huston the interview is pulled. Mostly everybody hates Brett as Brett knows all the station workers secrets. He has also written a memo insulting all of the main station players - Vic St. John - the station manager, Twyla Cooper - the producer, Chuck Gilmore - the sports reporter, Gary Slate - the weatherman, Cassie Woodfield - the reporter and Gillian Pope. Brett is shot dead with Gillian's gun and therefore is arrested for the crime. Gillian calls in Perry, Della and Ken to investigate. As Della and Perry set out to solve the mystery, Ken gets close to Cassie but she is a suspect and when it appears that somebody is trying to kill her, the mystery deepens..
A Bishop from Australia comes to Perry to ask him to take a case of a woman wrongly accused of manslaughter 22 years before. The case would involve the wealthy Mr. Brownley and the fact that his alleged granddaughter may be an imposter. With that, the Bishop leaves and is clubbed in his hotel room. Soon after, he leaves on a boat and Perry meets the woman - Ida Gilbert. Perry goes to see Mr. Brownley, but gets nowhere. Later that night, Brownley is to meet Ida, but he is shot by a woman who drops Ida's gun. Ida is arrested for the murder of Mr. Brownley and Perry gets involved.
The owner of a cosmetics company is unveiling a new cream which she claims she's been using. She's been keeping her age a secret and now reveals that she's 60 and owes her appearance to the cream. She's later killed and the formula missing. Her husband is arrested and Perry defends him.
Ken Malansky, a law student of Perry Mason's, is accused of murdering a fellow student. Perry is reluctant to take on his case as the victim was the son of a close friend.
A gangster who has commited all kinds of crimes is accused to have killed his wife. As he was not the murderer in this case Perry Mason intents to find the killer...
Sleazy talk show host Ted Mayne writes a tell-all book, which enrages and embarrasses several very prominent women. One of them, actress Roxanne Shield, loses her composure during an interview and winds up making a televised death threat. Of course, when Ted is murdered, she is arrested. Witnesses claim they saw Roxanne outside his apartment that night and police later find the murder weapon in her car. Renowned defence attorney Perry Mason accepts the challenge of defending her in court.
Anthony Caruso, an old friend of Perry Mason, comes to Denver on the request of Dee Morrison. She's married to famed photographer David Morrison, who wants to shoot a photo featuring his former models. The tricky thing is that all of his former models are also his former wives. But Dee knows Anthony can convince them to do it which he does. And David shoots them. Later Dee catches David it what appears to be in an inappropriate situation with his assistant. They have an argument and she leaves. Later David is found dead and she's arrested and Anthony defends her. And he suspects it could have been one of the wives
When his former secretary is accused of a murder, Perry Mason gives up a judgeship to defend her.
Perry Mason is invited to the marriage of the daughter of an old friend of his. But after the ceremony the uncle of the bride is dead. Certainly this is a case for Perry Mason.
A very nervous man named Cartwright comes into Perry's office to have the neighbor arrested for his howling dog. He states that the howling is a sign that there is a death in the neighborhood. He also wants a will written giving his estate to the lady living at the neighbors house. It is all very mysterious and by the next day, his will is changed and Cartwright is missing, as is the lady of the house next door. Perry has a will and a retainer and must find out whether he has a client or a beneficiary.
After giving the District Attorney another stinging defeat, Perry plans to take a vacation in China. That is, he was, until Rhoda, his old flame, meets him at a restaurant. It seems that her husband Moxley, who had been allegedly dead for four years, is alive and demanding money as she has married into wealth. The case escalates when the police find the body of Moxley and charge her with the murder.
A young theatre director is accused of killing a more famous Broadway director. Perry takes his case.
A painter, believed to be dead, returns to make allegations that a gallery owner is selling counterfeits of his work. Later, the artist is murdered.
An actor rigs a fake shooting on TV with the connivance of his friend, the show's host, but the practical joke goes wrong when the gun turns out to contain a live round.
The chief suspects in the murder of an author are the numerous colleagues whom he continuously plagiarized.
Perry Mason ventures to Paris to defend a U.S. Marine Corps Captain accused of murdering a man suspected of being a Nazi SS Officer.
A hockey player of friend of Ken Malansky's is accused of murdering a team owner. Perry takes the case.