Ken Malansky, a law student of Perry Mason's, is accused of murdering a fellow student. Perry is reluctant to take on his case as the victim was the son of a close friend.
When his former secretary is accused of a murder, Perry Mason gives up a judgeship to defend her.
An actor rigs a fake shooting on TV with the connivance of his friend, the show's host, but the practical joke goes wrong when the gun turns out to contain a live round.
A Bishop from Australia comes to Perry to ask him to take a case of a woman wrongly accused of manslaughter 22 years before. The case would involve the wealthy Mr. Brownley and the fact that his alleged granddaughter may be an imposter. With that, the Bishop leaves and is clubbed in his hotel room. Soon after, he leaves on a boat and Perry meets the woman - Ida Gilbert. Perry goes to see Mr. Brownley, but gets nowhere. Later that night, Brownley is to meet Ida, but he is shot by a woman who drops Ida's gun. Ida is arrested for the murder of Mr. Brownley and Perry gets involved.
The owner of a cosmetics company is unveiling a new cream which she claims she's been using. She's been keeping her age a secret and now reveals that she's 60 and owes her appearance to the cream. She's later killed and the formula missing. Her husband is arrested and Perry defends him.
A young theatre director is accused of killing a more famous Broadway director. Perry takes his case.
A very nervous man named Cartwright comes into Perry's office to have the neighbor arrested for his howling dog. He states that the howling is a sign that there is a death in the neighborhood. He also wants a will written giving his estate to the lady living at the neighbors house. It is all very mysterious and by the next day, his will is changed and Cartwright is missing, as is the lady of the house next door. Perry has a will and a retainer and must find out whether he has a client or a beneficiary.
A painter, believed to be dead, returns to make allegations that a gallery owner is selling counterfeits of his work. Later, the artist is murdered.
A young woman from Las Vegas wants Perry Mason to defend her father.
Perry Mason ventures to Paris to defend a U.S. Marine Corps Captain accused of murdering a man suspected of being a Nazi SS Officer.
Perry Mason defends the husband of a famous rock singer who was found being killed after having had a tremendous discussion with her husband and her manager.
Perry is at TV station "KGGY" to be interviewed but thanks to the interference of main anchor-person Brett Huston the interview is pulled. Mostly everybody hates Brett as Brett knows all the station workers secrets. He has also written a memo insulting all of the main station players - Vic St. John - the station manager, Twyla Cooper - the producer, Chuck Gilmore - the sports reporter, Gary Slate - the weatherman, Cassie Woodfield - the reporter and Gillian Pope. Brett is shot dead with Gillian's gun and therefore is arrested for the crime. Gillian calls in Perry, Della and Ken to investigate. As Della and Perry set out to solve the mystery, Ken gets close to Cassie but she is a suspect and when it appears that somebody is trying to kill her, the mystery deepens..
On the set of a popular daytime soap opera 'Mile High', actress Kris Buckner is being forced off by co-star Mark Stratton. When she says that she'll 'kill him before she leaves the show', she makes herself the prime suspect when Stratton is murdered by someone poisoning him. As an old friend, Perry Mason comes to the help of Kris and agrees to defend her. Meanwhile Ken goes in search of information with the help of fan of the show.
A priest is murdered and the main suspect is a nun.
Perry investigates the murder of a former madam and uncovers a multimillion dollar banking fraud in the process.
The chief suspects in the murder of an author are the numerous colleagues whom he continuously plagiarized.
A con man who stages phony "lucky legs" beauty contests and leaves town with the money is found with a surgical knife in his heart by Mason.
Lawyer Perry Mason is summoned to the Laxter mansion in the dead of night to write granddaughter Wilma out of invalid Peter Laxter's will, to keep her from marrying suspected fortune hunter Doug. Peter dies in a mysterious fire and Laxter's two grandsons, Sam Laxter and Frank Oafley, inherit his estate on the condition old caretaker Schuster and his cat Clinker are kept on. When cat-hating Sam threatens Clinker, Perry steps in and learns Laxter's death was suspicious and the family fortune and diamonds are missing. Schuster's found dead in his basement apartment, Laxter's nurse Louise is murdered with Schuster's crutch, and circumstantial evidence brings Doug to trial for Louise's death. Mason's investigation produces a surprise witness who turns the trial around. Written by Sister Grimm
Perry Mason is invited to the marriage of the daughter of an old friend of his. But after the ceremony the uncle of the bride is dead. Certainly this is a case for Perry Mason.
A gangster who has commited all kinds of crimes is accused to have killed his wife. As he was not the murderer in this case Perry Mason intents to find the killer...