Frozen River er historien om Ray Eddy, der begynder at smugle illegale indvandrere over grænsen fra Canada til USA for at supplere sin beskedne indtægt. Smuglingen sker i samarbejde med lyssky bagmænd og med livet som indsats fragter hun indere og pakistanere, som er stuvet sammen i bagagerummet på hendes Dodge, over den isdækkede St. Lawrence River. Men en nat går det galt.

An eighteen year old high school drop out and his twenty-seven year old friend start trafficking marijuana across the border of Canada in order to make money and their lives are changed forever.

A naive Canadian barber who knows US popular culture inside and out meets a flamboyant roadie who needs someone to drive her and her "brother's" corpse from Thunder Bay, Ontario to New Orleans. Chaos ensues after the barber agrees to drive her, the corpse, and the drugs stashed within all the way.