Queen Ramonda, Shuri, M'Baku, Okoye og Dora Milaje kæmper for at beskytte kongeriget Wakanda mod verdensmagter, der vil blande sig efter Kong T'Challas død. Mens wakandanerne stræber efter at omfavne deres næste kapitel, må heltene slutte sig sammen med hjælp fra War Dog Nakia og Everett Ross og skabe en ny vej for deres nation.

When her archaeologist father disappears on an expedition, Wanda sets out to look for him. What she finds is a secret underground world, where no one believes in life on the surface and where she and her father are taken for spies.

A party of archaeologists discovers the remnants of a mutant five millennia-old Sumerian civilization living beneath a glacier atop a mountain in Mesopatamia.