William Masters and Virginia Johnson are real-life pioneers of the science of human sexuality. Their research touched off the sexual revolution and took them from a midwestern teaching hospital to the cover of Time magazine and multiple appearances on Johnny Carson's couch. He is a brilliant scientist out of touch with his own feelings, and she is a single working mother ahead of her time. The series chronicles their unusual lives, romance, and unlikely pop culture trajectory.

Set in the year 1999, Dr. Arora is a curious comedy on the life and times of a sex consultant and his patients in the towns of Jhansi, Morena, and Sawai Madhopur. His profession, seemingly unique to the locals, results in serendipitous encounters that lead to unexpected enmities and unlikely friendships.