Part-American, part-Scandinavian death-metal band Dethklok has a lingering effect on its fans, who take the words seriously and do anything Dethklok lyrics say. The government fears the band's influence and sets out to destroy it by covert means; for example, by sending military pharmaceutical psychotropic drug manufacturers. Deemed sociopaths for tossing hot coffee at their concert attendees, two of the band members are alcoholics, and they all have self-esteem issues.

The Goodman family lives with their lovable pet dog, Mr. Pickles, a deviant border collie with a secret satanic streak.

Frustrated with her thankless office job, Retsuko the Red Panda copes with her daily struggles by belting out death metal karaoke after work.

Dominating the world of indie music, Detroit Metal City (DMC) is a popular death metal band known for its captivatingly dark and crude style. Its extravagant lead singer, Johannes Krauser II, is especially infamous as a demonic being who has risen from the fiery pits of hell itself in order to bring the world to its knees and lord over all mortals—or at least that's what he's publicized to be.

Unbeknownst to his many worshippers, Krauser II is just the alter ego of an average college graduate named Souichi Negishi. Although he is soft-spoken, peace-loving, and would rather listen to Swedish pop all day, he must participate in DMC's garish concerts in order to make ends meet. Detroit Metal City chronicles Negishi's hilarious misadventures as he attempts to juggle his hectic band life, a seemingly budding romance, and dealing with his incredibly obsessive and dedicated fans.

Series of 100 one-minute anime shorts that centers on Retsuko, a 25-year old red panda who works in her dream company's accounting department. But it turns out that she is forced to keep doing more and more impossible tasks by her superiors and co-workers. She doesn't talk back to them, but she still has to let off steam, so she ends up going to karaoke by herself and singing death metal.