Vincent er en kold og beregnende lejemorder, der anses for en af de bedste. Max er taxichauffør med store drømme, der aldrig bliver til noget. En skæbnesvanger nat kommer Max til at køre for Vincent, der er på vej ud for at udføre sin næste opgave. En nat, fem stop, fem attentater og en flugtscene. Deres skæbner knyttes sammen, og ingenting bliver nogensinde det samme igen. En nat der forandrer alt...
In an imaginary world where vehicles are the citizens, one underdog cabbie attempts to become king of the road in his hometown, Gasket City. He soon discovers that staying true to oneself is a greater pursuit than personal glory. When threatened by elitist attitudes and mobster trucks, can one unglamorous black and yellow ‘local zero’ rise to the challenge and become a ‘global hero’?
Amidst a backdrop of growing violence and intimidation, independent cab drivers struggling against a consolidated juggernaut rally around hot-tempered Matt Nolan. Nolan is determined to keep competition alive on the streets, even if it means losing the woman he loves.
Balkan Prince Henry has two wishes, to meet Lauren Bacall and see the "real" America. He befriends cabbie Buzz Williams and, without knowing the microphone is live, the two stage a debate on democracy versus monarchy broadcast back to the Prince's homeland. A plebiscite there puts Henry out of a job. Flying to Milwaukee to become a beer salesman, he meets Bacall on the seat next to his, but a tap on his shoulder means he must give up his seat (and dream) to Bogie.