Follow the adventures of Steve Austin, cybernetically enhanced astronaut turned secret agent, employed by the OSI, under the command of Oscar Goldman and supervised by the scientist who created his cybernetics, Rudy Wells. Steve uses the superior strength and speed provided by his bionic arm and legs, and the enhanced vision provided by his artificial eye, to fight enemy agents, aliens, mad scientists, and a wide variety of other villains.

Cyborg warriors were created by the Special Science Investigation Squad to bear nuclear, gravitational, magnetic, and electrical forces. They fight the crime empire known as "Crime".

據說從遠古流傳下來的最強兵器，它的名字叫做「WITCHBLADE」。它的存在就是戰鬥，但是啟動WITCHBLADE需要一樣必須的道具，那就是被她選中的命運之女。未來的東京，為了奪取這最強兵器的兩大組織：為了開發最強兵器的導示重工和通過遺傳因子來製造優秀人類的NSWF。兩大組織不擇手段的爭奪著只有被選中的女人(道具)才能操作的最強兵器「WITCHBLADE」。在地震災害6年後的東京，命運之女候選者天羽雅音一家的殘酷命運開始了……

Jaime Sommers is saved from death after receiving experimental medical implants. While adjusting to her new bionic powers and raising a rebellious younger sister, Jaime agrees to work for the Berkut Group, a quasi-governmental private organisation that performed her surgery.

在未來世界里，人類研發出了生理上與人類無異的仿生人，二者唯一差別就是可以被植入“初始執念”。由於該產業發展迅猛，有人開始利用其進行非法活動。政府最終出台“仿生人禁止令”。

　　政府成立“明眸搜查部”來配合搜查混跡在人類社會中未被發現的仿生人，調查員程諾（宋威龍 飾）和安秋（文淇 飾）在組長萬國峰（祖峰 飾）的帶領下展開工作。二人從開始的互看不慣到後來可以默契配合完成案件偵破。就在這個過程中，二人各自隱藏的秘密也漸漸浮出水面。