Τα κεντρικά γραφεία του μυαλού της έφηβης πλέον Ράιλι υφίστανται μια ξαφνική κατεδάφιση προκειμένου να δημιουργηθεί χώρος για κάτι εντελώς απροσδόκητο: νέα συναισθήματα! Η Χαρά, η Λύπη, ο Θυμός, ο Φόβος και η Αηδία, που εδώ και πολύ καιρό κάνουν καλή δουλειά, όπως και να το δει κανείς, δεν είναι σίγουροι πώς να αισθάνονται όταν εμφανίζεται η Ανησυχία. Και φαίνεται ότι δεν είναι μόνη.

Το να μεγαλώνεις είναι ένας ανώμαλος δρόμος, και η Ράιλι δεν αποτελεί εξαίρεση στον κανόνα. Θα αναγκαστεί να ξεριζωθεί από τη ζωή της σε κεντρο-δυτική πολιτεία, όταν ο πατέρας του βρίσκει νέα δουλειά στο Σα Φρανσίσκο. Όπως όλοι, η Ράιλι οδηγείται από τα συναισθήματα της: χαρά, φόβο, θυμό, αηδία και λύπη. Τα συναισθήματα αυτά ζουν στα Κεντρικά, το κέντρο ελέγχου στο μυαλό της μικρής και τη συμβουλεύουν σε κάθε της βήμα. Καθώς η Ράιλι και τα Συναισθήματα της προσπαθούν να προσαρμοστούν στη ζωή του Σαν Φρανσίσκο, στα Κεντρικά γίνεται ένας σάλος. Παρότι η Χαρά, το κύριο συναίσθημα της κοπέλας, προσπαθεί να κρατήσει μια αισιοδοξία, τα υπόλοιπα συναισθήματα παλεύουν να τα φέρουν βόλτα στη νέα πόλη, το νέο σπίτι και το νέο σχολείο.

Η Ράιλι, τώρα 12 ετών, κάθεται στο σπίτι με τους γονείς της στο Σαν Φρανσίσκο όταν εμφανίζεται ένας ενδεχόμενος κίνδυνος: ένα αγόρι χτυπάει την πόρτα.

Ο Florentino Ariza (Javier Bardem) έζησε την απόρριψη σε νεαρή ηλικία, από την όμορφη Fermina (Giovanna Mezzogiorno) και έκτοτε εστίασε στις σαρκικές απολαύσεις για να προσπαθήσει να γιατρέψει την πληγωμένη του καρδιά.

Σε μια φουτουριστική και ουτοπική κοινωνία, τα ανθρώπινα συναισθήματα έχουν ξεριζωθεί τελείως και όλοι ζουν εν ειρήνη. Όταν όμως παρουσιάζεται μια νέα ασθένεια, όλα αλλάζουν για τον εικονογράφο Σίλας. Αφού μολυνθεί, γίνεται ένας απόκληρος και βρίσκει συγκατάβαση μονάχα από τη συνάδελφο του, συγγραφέα Νία, η οποία είναι επίσης μολυσμένη αλλά το κρύβει. Αυτό που αντιλαμβάνονται και οι δύο είναι ότι για να επιβιώσουν, πρέπει να δραπετεύσουν.

After twelve years in prison, Walter returns home. His family has abandoned him, save for his brother-in-law. Few know he's a sex offender and pedophile. Walter finds an apartment and is regularly visited by his parole officer. He gets a job at a lumber mill and starts seeing a coworker. Then his new world begins to unravel; as his past becomes known, he strikes up a high-risk friendship with a young girl and realizes that a man loitering near a schoolyard is a child molester prowling for his next victim.

Thief Gaston Monescu and pickpocket Lily are partners in crime and love. Working for perfume company executive Mariette Colet, the two crooks decide to combine their criminal talents to rob their employer. Under the alias of Monsieur Laval, Gaston uses his position as Mariette's personal secretary to become closer to her. However, he takes things too far when he actually falls in love with Mariette, and has to choose between her and Lily.

Five years have passed and Jake has turned his back on his family. He's still up to his usual tricks in McClutchy's Bar, unaware, as he downs his latest opponent, that his eldest son, Nig, has died in a gang fight. The uncomfortable family reunion at Nig's funeral sparks a confrontation with second son, Sonny, and sets Jake and Sonny on a downward spiral.

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