Dr. Daniel Pierce, a neuroscientist and professor, is recruited to help the federal government crack difficult cases. His intimate knowledge of human behavior and masterful understanding of the mind give him an extraordinary ability to read people, but his eccentric view of the world and less-than-stellar social skills can often interfere with his work.

Sydney Fox is a professor and globe-trotting "relic hunter" who looks for ancient artifacts to return to museums and/or the descendants of the original owner. She is aided by her linguistic assistant Nigel and occasionally by her somewhat air-headed secretary Claudia. She often ends up battling rival hunters seeking out artifacts for the money.

An alien who came to Earth 400 years ago is almost able to return to his own planet, but when he meets a famous actress, he doesn't want to go home.

Declan Dunn has a fascination with mystical phenomena that began when he was buried under an avalanche and given up for dead. After he miraculously survived, he committed his life to investigating miracles and the absolute proof of their existence. Now a professor of Anthropology at a leading Oregon university, Declan has the training, support staff and the opportunity to study the uncanny, inexplicable phenomena people call "miracles". With the help of Peggy, a skeptical psychiatrist, and Miranda, a research student, the three embark on a quest to explain what science cannot.

Alec Mercer is a world-renowned professor of behavioral psychology with a unique insight into human nature who lends his expertise to an array of high-stakes cases involving governments, corporations and law enforcement. However, he meets his match in a female domestic terror suspect who turns his world upside down.

Pursuit of Happiness is an American sitcom that aired on ABC from October 30, 1987 to January 22, 1988.