เรื่องราวของแพทริค เจน (ไซม่อน เบเกอร์) จิตแพทย์ชื่อดังที่เสียลูกและเมียไปด้วยน้ำมือของฆาตกรฆ่าต่อเนื่องนาม เรด จอห์น ซึ่งแพทริคจะใช้ความสามารถในอ่านใจ วิเคราะห์จิต สังเกตุพฤติกรรมต่างๆเพื่อช่วยตำรวจในการนำคนร้ายมาลงโทษด้วยกฏหมายในแต่ละตอน
หลังจากมอบตัว อาชญากรอัจฉริยะเสนอตัวเองเพื่อช่วยเอฟบีไอจัดการกับคนชั่ว โดยมีข้อแม้ว่าต้องได้นักวิเคราะห์พฤติกรรมมือใหม่เอลิซาเบธ คีนมาเป็นคู่หูเท่านั้น
เมื่อนักสืบมือใหม่โน้มน้าวตำรวจว่าเขามีพลังจิต เขาและเพื่อนสนิทที่ไม่เต็มใจก็ได้รับการว่าจ้างให้เป็นที่ปรึกษาเพื่อช่วยแก้ไขคดีที่ซับซ้อน
Adrian Monk was once a rising star with the San Francisco Police Department, legendary for using unconventional means to solve the department's most baffling cases. But after the tragic (and still unsolved) murder of his wife Trudy, he developed an extreme case of obsessive-compulsive disorder. Now working as a private consultant, Monk continues to investigate cases in the most unconventional ways.
After a serial killer imitates the plots of his novels, successful mystery novelist Richard "Rick" Castle receives permission from the Mayor of New York City to tag along with an NYPD homicide investigation team for research purposes.
Dr. Mark Sloan is a good-natured, offbeat physician who is called upon to solve murders.
In exchange for his freedom, charming con artist Neal Caffrey provides his expertise to help straight-man FBI agent Peter Burke catch elusive white-collar criminals.
Allison Dubois works in the District Attorney’s office using her natural intuition about people and her ability to communicate with the dead to help to solve crimes. Her dreams often give her clues to the whereabouts of missing people.
A retired FBI serial-profiler joins the mysterious Millennium Group, a team of underground ex-law enforcement experts dedicated to fighting against the ever-growing forces of evil and darkness in the world.
The world's leading deception researcher, Dr. Cal Lightman, studies facial expression, body language and tone of voice to determine when a person is lying and why, which helps law enforcement and government agencies uncover the truth. But his skills also make it easier for him to deceive others.
An unassuming mystery writer turned sleuth uses her professional insight to help solve real-life homicide cases.
Toby Logan is a highly skilled paramedic with a secret – he can read minds. Toby never really knew his parents and grew up in foster care, this coupled with his secret, which he shares with no one, has made him a bit of a loner. Until now, Toby has kept his ability hidden, exploring its possibilities only with his long time mentor and confidante Dr. Ray Mercer.
Both a gift and a curse, Graham has the extraordinary ability to think like his prey—he sees what they see, feels what they feel. But while Graham is pursuing an especially troubling, cannibalistic murderer, Special Agent Jack Crawford teams him with a highly respected psychiatrist – a man with a taste for the criminal minded – Dr. Hannibal Lecter.
Clinical psychologist Dr Tony Hill's uncanny ability to see into the minds of murderers means he finds it difficult to distance himself from disturbing cases.
Dr. Daniel Pierce, a neuroscientist and professor, is recruited to help the federal government crack difficult cases. His intimate knowledge of human behavior and masterful understanding of the mind give him an extraordinary ability to read people, but his eccentric view of the world and less-than-stellar social skills can often interfere with his work.
Jess Mastriani was a normal person who only wanted to take over her parents' restaurant in Indiana. But that changed when she was hit by lightning. After that she began seeing visions of missing people. Jess decides to use her newfound ability to be a consultant to the FBI, helping locate missing individuals. Eventually, she is hired by the bureau full-time and trained to become an agent, but her by-the-book nature sometimes clashes with the personality of her partner. Jess and her colleagues work out of the FBI's Washington, D.C., office.
A former underworld lawyer goes to work for the Federal Government, determined to bring 100 top criminals to justice.
Dr. Dylan Reinhart, a gifted author, university professor and former CIA operative is lured back to his old life by tenacious top NYPD Detective Lizzie Needham. Though Dylan and Lizzie initially clash, when it comes to catching killers, they make an ideal team.
Malcolm Bright (Tom Payne) ที่เป็น Criminal Profiler โดยที่พ่อของเขา Dr. Martin Whitly (Michael Sheen) คือ ฆาตกรต่อเนื่อง The Surgeon ซึ่งถูก Malcolm เป็นคนแจ้งเบาะแสให้กับตำรวจเพื่อจับพ่อของตัวเอง และไม่ได้เจอหน้าพ่อมาเป็นสิบปี จู่ๆ วันนึงก็ได้รับการติดต่อจาก Gil Arroyo (Lou Diamond Phillips) นักสืบของ NYPD และผู้ที่เป็นพ่ออุปถัมป์ของ Malcolm เอง ว่ามีฆาตกรเลียนแบบวิธีการฆ่าของ The Surgeon ทำให้ Malcolm ต้องกลับมาร่วมงานกับทาง NYPD และต้องไปพบพ่อของตัวเองที่ไม่ได้เจอกันมาเป็นสิบปี โดยใช้ความรู้ของ Dr. Martin ในการตามจับคนร้าย และในขณะเดียวกัน เขาก็ต้องต่อสู้กับปีศาจร้ายในจิตใจของตัวเองไปด้วยเช่นกัน
Erica Shepherd is a brilliant former CIA operative, now known as the most notorious traitor in American history serving life in a Supermax prison. Against every fiber of his being but with nowhere else to turn, FBI Agent Will Keaton enlists Shepherd to help track down a fiercely dangerous and elusive criminal she knows all too well. While Shepherd and Keaton have different motivations for bringing the enemy to justice, they both know that to catch a spy… they must think like one.