凱西（詹妮弗·安妮斯頓 Jennifer Aniston 飾）是個年近四十的單身女人，她有工作，有朋友，盡情享受單身生活，也萌生了生一個小孩獨自撫養的想法。聯繫相關機構後，凱西找到和合適捐精人——完美先生羅納德（傑夫·高布倫 Jeff Goldblum 飾），不想在好友為她舉辦的「受孕派對」上，她最好的朋友沃利（傑森·貝特曼 Jason Bateman 飾）在衛生間氣惱地換掉了羅納德的精液。原來沃利一直愛著凱西，只是二人做好友太久了，已經失去了走在一起的最佳時機，就這樣眼睜睜看著凱西離開自己。一別七年，凱西再次回來紐約居住時，帶回了7歲的早熟小孩塞巴斯蒂安，迎接他們歸來的沃利輕易發現塞巴斯蒂安和自己的相似，他想適時告訴凱西真相順便表白，不想羅納德也再度出現在凱西生活裡……

In a massive, mysterious chamber, fifty strangers awaken to find themselves trapped with no memory of how they got there. Organized in an inward-facing circle and unable to move, they quickly learn that every two minutes, one of them must die…executed by a strange device in the center of the room.

Alyssa wakes up in a home that's not hers and discovers a dead body. With no memory of how she got there, and no idea of who he is, Alyssa tries to piece together what exactly happened the night before.

John is a brilliant linguistic scientist with a loving wife and daughter but with a massive gap in his life. Eight years ago, he turned up out of nowhere, with no memories except a recurring dream. He is sent tumbling down the proverbial rabbit hole after meeting a man that shares a similar condition and learning that there are more like him, all amnesiacs with extraordinary abilities. He convinces his brother-in-law, private investigator Carl, to help him uncover his true identity before his past can rise up to destroy him and his family.

Jane Ravenson finds herself in the middle of a grocery store with $10,000 in her coat pockets and no memory of her life or who she is. Her husband eventually finds her and she starts to believe that her family life is fine until she feels a deep, nightmarish paranoia that something is horribly and terribly wrong.