Having met on a train, a smooth-talking psychotic socialite shares his theory on how two complete strangers can get away with murder to an amateur tennis player — a theory he plans to test out.

As a result of nuclear testing, gigantic, ferocious mutant ants appear in the American desert southwest, and a father-daughter team of entomologists join forces with the state police officer who first discovers their existence, an FBI agent and, eventually, the US Army to eradicate the menace, before it spreads across the continent — and the world.

Roy Morgan is a burglar who listens in to radio police calls, allowing him to stay one step ahead of the cops. After Morgan kills a police officer, Sergeants Brennan and Jones have little success in putting the clues of the case together. But when Jones is wounded in a shoot-out with Morgan, Brennan employs all facets of detective work, including forensics and informants, to find the elusive and clever criminal.

Professional Squatchers Huckleberry and Scott Chuck travel from the deep south to New York city to track down the mythical monster; Bigfoot.