Ocorre aproximadamente dez anos antes dos eventos da série original Star Trek, ST: Discovery mostra as casas unidas dos Klingons envolvendo-se em uma guerra com a Federação Unida de Planetas. Os protagonistas são os tripulantes da USS Discovery.

Ryuichiro's bride, company president Mayumi Kitahara dies, leaving him to take care of her daughter Natsumi. Natsumi moves into Ryuichiro's flat, but he sets to work to be the father she never had.

Segawa Yuta is a freshman of a university. He lost his parents when he was small and was raised by his sister Yuri. Yuta has been living alone since Yuri got married to a middle aged man when Yuta was a junior high student.  One day, Yuri visited Yuta's apartment and asked him to take care of her three daughters while Yuri and her husband were on a trip. He unwillingly accepted the job but the plane Yuri took went missing. In order to prevent the daughters from being adopted separately by relatives, Yuta decided to take in all three girls.  A life of a strange family in a tiny apartment begins.

At a major university, the first woman of color to become chair tries to meet the dizzying demands and high expectations of a failing English department.

Seven-year-old Jess is removed from her peculiar Pentecostal home and sent to school.

Sophie grew up in a wealthy and musically talented family. Luoshan is the daughter of Sophie's parents' chauffeur. When Luoshan's father dies in an accident while driving drunk, she is adopted by Sophie's family and takes the name Susan instead of Luoshan. Thereon, Susan plans to take whatever Sophie has.