傳說戴著面具四出行俠仗義的「 獨行俠」是這樣出現的⋯⋯一班騎警在追捕土匪「食人魔」時突遭伏擊，唯一生還者警長弟弟約翰（艾美爾咸瑪飾演）矢志為兄復仇，碰巧遇上以捉拿「食人魔」為使命的怪雞紅番湯圖（尊尼特普飾演），二人於是成為戰友並肩作戰，但性格和處事方式卻總是唔多合拍。他們走遍千里追蹤「食人魔」，竟發現橫貫美洲大陸的鐵路原來背後藏有巨大陰謀，更牽涉驚天秘密⋯⋯

Two outlaws, The Lonely Rider and the Indian Tonto, have caught (at least they think they have) Speedy Gonzales, a ruthless gunfighter from the town of Njietponimaistadi. They start to travel to another town for the reward, through the desert without water and fighting against Indians. And just to find out that they have made a full circle back to origin.