紐約中央公園動物園裡的明星動物:獅子、班馬、長頸鹿和河馬，某次意外的從動物園逃脫，被抓到後被遣送回非洲，途中卻意外流落到位處非洲東南外海印度洋上的馬達加斯加島。這些一出生就住在動物園的都市動物們該如何在野外求生存?
改編自法國漫畫。布魯斯威利飾演一位2035年的監獄犯詹姆斯柯爾。他被指派回到地球環境尚未惡化前的過去，阻擾致命的瘟疫大流行。這種濾過性病毒害死了大部分的人類，使得其他殘存的人類只好活在暗無天日的地下。 時空機器將他送回1990年。沒想到，一回到過去的他，被人為成瘋子，送進了神精病院。而在此時他結識了布萊德彼特所飾的傑弗瑞。不久，認識了另一個凱薩琳蕾莉博士（麥德琳史道威飾）。詹姆斯說服了凱薩琳接受了他是個未來人的事實，可是同時，他必須趕快找到那個散播病毒的罪魁禍首…… 在他調查的過程，發現有個環保組織所用符號，竟與未來世界裡的一模一樣，而那個瘋子傑弗瑞正好是組織裡的頭兒……可是聽起來他們也不過是保護地球自天環境而已，應該不會和破壞生命的病毒撤上關係吧？ 詹姆斯在查不出來之餘，想與相愛的凱薩琳坐飛機逃了出去，此時，他正好發現那個帶病毒的人，他奮不顧身的追了過去……
A sinister corporation loses control of a house cat infected with a genetically-engineered virus. The death-toll rises during the mutant feline's rampage, and eventually, it finds its way on board a ship of a criminal king-pin.
一家人在農場附近遭到殺害，阿姆斯特丹的警方找不到任何線索，獸醫麗茲卻發現了關鍵跡象，使她懷疑兇手是一隻大獅子。一開始，她的理論不被重視，但在更多受害者出現後，人們開始相信這隻猛獅已經入侵阿姆斯特丹了。政府請來英籍的大型動物獵人與麗茲合作。然而，在調查的同時，她還得確保自己身為記者的男友不會為了新聞失了分寸。而另一邊，大開殺戒的獅子已即將讓整個城市變成牠的狩獵場。
A tiger escapes from a circus truck as it passes by a small town, and hides itself in the surrounding woods. This throws the town into a panic and everyone wants the animal killed immediately, except for the daughter of the sheriff. She wants to capture the tiger and put it in a zoo, thereby saving the tiger's life. Her determination starts a nationwide campaign among children to raise the money to buy the tiger from the circus, but first, she, her father and an Indian tiger trainer must find the tiger before the National Guard do, who have orders to kill it on sight.
A young boy lets the animals out of their cages at the Zoo, to set them free, but the animals start taking over the town.
A wildcat escapes from the zoo, disguises herself as a skunk to fool her pursuers, but that only attracts lovestruck Pepe le Pew.
Panic grips a small community after a tanker truck crashes through a fence at a wild animal park, freeing dozens of dangerous beasts.
In this Pete Smith Specialty short, two lion cubs escape from the zoo and go on an adventure.
A witness to his mother’s death at the hand of a man, the coyote, Chico, has learned to hate and fear him. Taken into captivity and exhibited in a small desert roadside zoo, he learns much but never loses his bitterness toward his enemy: man. Chico makes his escape and bounds off for a life of adventure in the desert where he mates with Tula. He sees an eagle grab one of his pups and worries when his mate raids a chicken coop. Realizing the dangers of man, Chico decides to take his family deeper into the desert to help his family try to win the battle for survival.
In a small village in north of Sweden lives a calf that dislikes enclosures. The desperate farmer builds fence after fence, but the calf still manages to get out. When a film team arrives to make a film about the events, everything changes.