Abtrünnige Wissenschaftler wollen die Weltbevölkerung ausdünnen, indem sie die schlafenden Monster der Erde erwecken. Nun ist es an Godzilla, die Titanen aufzuhalten.

A 17th-century Caribbean port rumored to have frequented by pirates rises from the ocean floor, where it came to rest after an earthquake many years before. A scientist wants to study it, some thugs want the treasure alleged to be stored there, a bunch of mutated giant crabs living there attack them all.