1차 세계 대전 말 뉴올리언즈. 80세의 외모를 가진 아기 벤자민 버튼이 태어난다. 사랑하는 아내가 벤자민을 낳다 세상을 떠난 것에 대한 분노와 아이의 평범하지 않은 외모에 경악한 벤자민의 아버지는 분노를 참지 못하고 그를 놀란 하우스 양로원 현관 앞에 버린다. 놀란 하우스에서 일하는 퀴니에게 발견된 벤자민. 퀴니를 엄마로, 그곳의 할아버지, 할머니들을 친구로 살아가는 벤자민은 해가 갈수록 젊어지는 자신을 발견한다. 12살이 되어 60대 외형을 가지게 된 벤자민은 어느 날, 할머니를 찾아온 6살의 어린 데이지를 만난다. 그리고 데이지의 푸른 눈동자를 영원히 잊을 수 없게 된다.

This is a movie about two scientists who invent a time machine. A critical part falls out of the time machine before they get into it to test it. Nothing seems to happen at first, but when they wake up the next day they are regressing in age (physically and mentally).

The head of a major cosmetics company experiments on herself with a youth formula made from royal jelly extracted from wasps, but the formula's side effects have deadly consequences.

Two elderly roommates at a hospice are randomly selected for a Gene-Therapy Trial that rejuvenates their bodies, making them younger. Given a second chance at love, lust and life, with the memories of their past life intact, they now must find their place in a new world that has left them behind.

As a director faces a series of setbacks in life including debt and divorce, his elderly father suddenly regains his youth.

What if science could reverse the aging process? Follow the researchers as they decipher these mechanisms, with the promise of finding the elixir of youth so you can live longer, healthier lives!