Πίσω από τα τείχη του Βατικανού ο συντηρητικός Πάπας Βενέδικτος και ο φιλελεύθερος μελλοντικός Πάπας Φραγκίσκος πρέπει να βρουν κοινό έδαφος για να συνεχίσουν την πορεία της Καθολικής Εκκλησίας.

Cardinal Lawrence is tasked with leading one of the world's most secretive and ancient events, selecting a new Pope. Once the Catholic Church’s most powerful leaders have gathered from around the world and are locked together in the Vatican halls, Lawrence finds himself at the center of a conspiracy and discovers a secret that could shake the very foundation of The Church.

In 1458, five years after the fall of Constantinople to the Turk, eighteen cardinals meet to elect a new pope. Rodrigo Borgia, a 27 year old cardinal learns to play a very dangerous game.