Megamind's former villain team, The Doom Syndicate, has returned. Our newly crowned blue hero must now keep up evil appearances until he can assemble his friends (Roxanne, Ol' Chum and Keiko) to stop his former evil teammates from launching Metro City to the Moon.

In 2010, a scientist discovers aliens in orbit that resemble a cross between H.R. Giger's famous creation and Predator who want to invade Earth. They choose to start their invasion in Ghana because it is the most peaceful nation on the planet. The murderous aliens claim that they will have the entire planet colonized by the year 2016.

An intruder dressed in a Krampus mask breaks into a teenage Christmas party.